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Digitale Medien

Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline (1988)

Flückiger, E. ; Briner, U. ; Clark, B. ; [weitere]

Springer

Cellular and molecular life sciences 44 (1988), S. 431-436

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Details

ISSN: 1420-9071

Schlagwort(e): CQP 201-403 ; 8α-amino-ergolines ; ergot pharmacology ; D-2 agonist ; endocrine ; CNS ; cardiovascular actions

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The profile of action in animals of CQP 201-403, a novel 8α-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel®).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01940539

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