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  • 1
    Electronic Resource
    Electronic Resource
    On the lysis of paroxysmal nocturnal hemoglobinuria erythrocytes by complement: Dual role of C3b (1982)
    Springer
    Annals of hematology 45 (1982), S. 249-259 
    Details
    ISSN: 1432-0584
    Keywords: Complement, C3b ; Hemoglobinuria, paroxysmal ; Anemia, hemolytic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficiency of cytolysis by the terminal complement proteins C5b-9 can be markedly enhanced by C3b molecules bound on the target cell membrane (Hammer et al. 1976). This enhancement was shown to be proportional to the number of C3b molecules on the cell membrane. The present experiments have shown that the hemolytic efficiency of the complement membrane attack system is two to five times greater on paroxysmal nocturnal hemoglobulinuria erythrocytes (PNHE) than on normal human E. This difference is attribut to a derivative of C3, probably C3b, on PNHE since it was abolished by anti-C3 but not by anti-C2. The efficiency of C5b-9 to lyse PNHE was only partially decreased by C3b inactivator and β 1H, indicating that the C3b on PNHE is not readily inactivated by its regulatory proteins. Furthermore, cells from a single severely affected patient consumed 3-fold more C5b6 than normal human E yet concommitantly measured membrane fluidity was normal. From these observations we conclude that cell-bound C3b on PNHE serves two functions: (a) it increases the hemolytic efficiency of membrane attack components of the complement system; and (b) it provides sites for assembly of the alternative pathway convertases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320192
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  • 2
    Electronic Resource
    Electronic Resource
    LCVD of copper: Deposition rates and deposit shapes (1986)
    Springer
    Applied physics 40 (1986), S. 1-5 
    Details
    ISSN: 1432-0630
    Keywords: 81.15.Gh ; 82.30.Lp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Laser chemical vapor deposition of copper has been performed under a variety of conditions. The results are interpreted using the kinetic model of Ehrlich and Tsao. We find that the kinetics of the process are limited by the rates of surface reactions and not by diffusion of reactant molecules to the surface. Furthermore, we find that deposit shapes are quite sensitive to laser intensity and scan rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00616584
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    Paper (German National Licenses)
    Fulltext
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