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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Medical & biological engineering & computing 31 (1993), S. S12 
    ISSN: 1741-0444
    Schlagwort(e): AIDS research ; Databases ; Information systems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract An information system has been established at the National Institute for Biological Standards & Control for the exchange of knowledge in AIDS research, particularly in relation to vaccine design. This system, the AIDS information exchange link (Ariel), is designed to act as a central store of relevant information for scientists in the UK and abroad and was set up under the auspices of the Medical Research Council. It holds information on research materials (reagents), on genetic sequences and on projects. Several computers and database systems are involved. Access is obtained through Janet, the UK academic network, or PSS, the British Telecom public network. Both these networks are linked to international network systems, e.g. Internet, Earn, IPSS. Ariel has been in operation for 18 months and is accessed internationally.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1045-4861
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin , Technik allgemein
    Notizen: Hydroxyapatite induction by a synthesized pure silica hydrogel was examined in various simulated body fluids (SBFs) having different magnesium, calcium, and phosphate ion concentrations as well as pH values. The silica hydrogel generated biologically active apatite on its surface by taking up calcium and phosphorous ionic groups from a surrounding SBF that was prepared to emulate the human plasma in inorganic composition. The induction period for apatite nucleation on the surface of the silica was largely decreased with the addition of a small amount of the calcium or phosphate ions to the SBF and with an increase in pH, but increased with the addition of magnesium ion. Bioactivity of bioactive materials like Bioglass® and glass-ceramic A-W was well interpreted in terms of the rate of apatite formation reflected in these results. Moreover, the results provide the basic knowledge for designing new bioactive materials. © 1993 John Wiley & Sons, Inc.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 34 (1997), S. 79-86 
    ISSN: 0021-9304
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin , Technik allgemein
    Notizen: The bone-bonding polymer known as Polyactive® is a block copolymer composed of a polyethylene oxide (PEO) soft segment and a polybutylene terephthalate (PBT) hard segment. This study focuses on the in vitro induction of hydroxyapatite by Polyactive®. Our results show that Polyactive® is capable of inducing hydroxycarbonate apatite (HCAp) formation from a metastable calcium phosphate solution analogous to a physiological solution. In a 4-day incubation, the HCAp formation extended approximately 100 μm deep from the surface. A great number of globules about 1 μm large were found in the calcified Polyactive®. These globules were composed of HCAp crystals embedded in the polymer matrix. There were so many globules in the surface that they connected with each other and formed a calcified layer. Next to the calcified layer was a zone where the globules were scattered. The calcified surface may have acted to promote HCAp growth from the solution, bringing about the formation of a HCAp layer on top of the calcified layer. The transition of solid Polyactive® into a Polyactive® hydro-gel in calcium phosphate solution permitted HCAp formation within the polymer. It is proposed that the COOH groups produced during hydrolysis of Polyactive® play an important role in nucleating hydroxyapatite. A remarkable affinity of the PEO segment of the polymer for calcium ions may facilitate moving calcium and phosphate from the solution into the polymer for the growth of HCAp. © 1997 John Wiley & Sons, Inc.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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