ISSN:
1573-6903
Keywords:
2,6-Diisopropylphenol (propofol)
;
general anaesthesia
;
glutamate-dependent Ca2+ uptake
;
ATP-dependent glutamate uptake
;
ATPase
;
rat synaptosomes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract 2,6-diisopropylphenol (propofol), a general intravenous anesthetic, inhibits the glutamate-dependent Ca2+ entry in rat synaptosomes with an approximate IC50 of 3.0×10−5 M.Propofol, at concentrations above 10−6M, also inhibits the ATP-dependent uptake of glutamate in the presence of Ca2+, with an approximate IC50 of 3.5×10−5M, while it only has a slight inhibitory effect on the release of glutamate. The ouabain-insensitive synaptosomal ATPase is strongly inhibited by propofol, with an IC50 of about 2.5×10−6M, at concentrations which do not affect the luciferase system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00965564
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