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  • Amphetamine  (5)
  • Patch clamp  (5)
  • Abdomen  (3)
  • 1
    Digitale Medien
    Digitale Medien
    A syndrome of multiple gastrointestinal atresias with intraluminal calcification (1979)
    Springer
    Pediatric radiology 8 (1979), S. 227-231 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Abdomen ; Calcification, bile ducts ; Biliary gas, gastrointestinal ; Atresias
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract An infant with multiple gastrointestinal atresias from the stomach to the rectum is reported and the literature concerning this syndrome is reviewed. The syndrome has been reported, to date, exclusively in infants born to families with a French-Canadian background. The radiological hallmark of this syndrome is extensive calcification of intraluminal content between the areas of atresia which appears as rounded or oval homogeneous radiopacities on abdominal radiographs. Inheritance is thought to be autosomal recessive and the etiology is uncertain. All previously reported cases have died. The significance of biliary gas, seen in postoperative films, is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00974040
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  • 2
    Digitale Medien
    Digitale Medien
    Congenital epithelial splenic cysts in children (1982)
    Springer
    Pediatric radiology 12 (1982), S. 119-125 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Spleen ; Cysts ; Ultrasound ; Abdomen ; Mass
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The clinical, radiographic and sonographic features of four children with congenital epithelial splenic cysts are described. All four cases presented with a left upper quadrant mass and few symptoms. In one case the spleen descended into the pelvis in the upright position. In three cases the sonographic findings showed the mass to be completely sonolucent. In the fourth case the mass was echogenic and echoes were distributed homogeneously throughout the mass. These internal echoes were due to the presence of fat droplets within the cyst fluid. Internal echoes may also be due to hemorrhage into the cyst. In all four cases a rim of splenic tissue was visible around part of the cyst.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00971799
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  • 3
    Digitale Medien
    Digitale Medien
    Unusual renal distortion and displacement due to the spleen (1982)
    Springer
    Pediatric radiology 12 (1982), S. 185-189 
    Details
    ISSN: 1432-1998
    Schlagwort(e): Abdomen ; Computed tomography ; Pseudomasses ; Kidney ; Displacements ; Distortions ; Spleen ; Lobulation ; Variants
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Occasional normal anatomic variations may produce radiographic appearances that closely simulate disease and visceral enlargement may cause unusual displacements of adjacent organs. Two cases are reported in whom prominent splenic lobulation caused flattening of the upper pole of the left kidney. The appearance simulated that produced by a suprarenal mass. The value of CT in differentiating this normal variation from disease is discussed. A third patient in whom massive splenomegaly caused upward displacement of the left kidney is also reported. The literature concerning visceral relationships in the left upper quadrant and the normal variations that simulate disease is reviewed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00999308
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  • 4
    Digitale Medien
    Digitale Medien
    Nicotine as a discriminative cue in rats: Inability of related drugs to produce a nicotine-like cueing effect (1972)
    Springer
    Psychopharmacology 27 (1972), S. 379-387 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Nicotine ; State-Dependent Behavior ; Lobeline ; Amphetamine ; Arecoline
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Rats were trained to enter one arm of a T-maze after the subcutaneous administration of 0.4 mg/kg and to enter the opposite arm following the injection of an equal volume of saline. Administration of 0.4 mg/kg nicotine isomethonium iodide hydroiodide, 0.4–10.0 mg/kg lobeline sulfate, 2.0 and 4.0 mg/kg d-amphetamine sulfate and 0.25–2.0 mg/kg arecoline hydrobromide produced responses which resembled the established saline effect. Pretreatment with 10.0 mg/kg lobeline had no significant effect on the nicotine-cued response. The inability of these structurally and/or functionally similar drugs to produce a nicotine-like discriminative effect is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429392
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  • 5
    Digitale Medien
    Digitale Medien
    Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training (1990)
    Springer
    Psychopharmacology 102 (1990), S. 221-226 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Drug discrimination ; Norfenfluramine ; Amphetamine ; Pentobarbital ; Session-to-criterion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245925
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  • 6
    Digitale Medien
    Digitale Medien
    Dopaminergic mediation of the interoceptive cue produced by d-amphetamine in rats (1975)
    Springer
    Psychopharmacology 42 (1975), S. 185-193 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Amphetamine ; Dopamine ; Haloperidol ; State-Dependent Behavior ; Apomorphine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract After rats were trained to differentiate between the effects of d-amphetamine and saline in a state-dependent task, pretreatment with the tyrosine hydroxylase inhibitor, α-methyl-p-tyrosine, significantly decreased amphetamine discrimination. Pretreatment with the dopamine-Β-hydroxylase inhibitor, disulfiram, or with the tryptophan hydroxylase inhibitor, p-chloro-phenylalanine, was observed to have no effect on the rats' ability to discriminate d-amphetamine. Administration of haloperidol, a selective dopamine receptor blocker, completely abolished the amphetamine discrimination, whereas α- and Β-adrenergic receptor blockade had no effect. Apomorphine, a dopamine receptor stimulant, produced amphetamine-like responses and this was, likewise, abolished by pretreatment with haloperidol. These data suggest that dopaminergic systems mediate the interoceptive cue produced by d-amphetamine in rats, and these results are discussed in relation to possible dopamine mediation of amphetamine psychosis and paranoid schizophrenia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00429551
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  • 7
    Digitale Medien
    Digitale Medien
    Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 399-405 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Sodium channel ; Oocyte ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Na currents recorded from inside-out macropatches excised from Xenopus oocytes expressing the α subunit of the rat brain Na channel IIA show at least two distinguishable components in their inactivation time course, with time constants differing about tenfold (τ h1 = approx. 150 μs and τ h2 = approx. 2 ms). In excised patches, the inactivation properties of Na currents changed with time, favoring the faster inactivation kinetics. Analysis of the fast and slow current kinetics shows that only the relative magnitudes of τ h1 and τ h2 components are altered without significant changes in the time constants of activation or inactivation. In addition, voltage dependence of both activation and steady-state inactivation of Na currents are shifted to more negative potentials in patches with predominantly fast inactivation, although reversal potentials and valences remained unaltered. We conclude that the two inactivation modes discerned in this study are conferred by two states of Na channel the interconversion of which are regulated by an as yet unknown mechanism that seems to involve cytosolic factors.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00374253
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  • 8
    Digitale Medien
    Digitale Medien
    Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches (1994)
    Springer
    Pflügers Archiv 427 (1994), S. 406-413 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Sodium channel ; Oocyte ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Macroscopic currents of wild-type rat brain IIA (RBIIA) and mutant Na channels were recorded in excised patches from Xenopus oocytes. A charge deletion (K859Q) and an adjacent conservative mutation (L860F) in the second domain S4 membrane-spanning region differentially altered voltage sensitivity and kinetics. Analysis of voltage dependence was confined to Na currents with fast inactivation kinetics, although RBIIA and K859Q (but not L860F) also showed proportional shifts between at least two gating modes, rendering currents with fast or slow inactivation kinetics, respectively. Compared to RBIIA, the midpoint of the activation curve was shifted in both K859Q and L860F by 22 mV to more positive potentials, yet this shift was not associated with a corresponding change in the voltage dependence of time constants for activation (τ a) or inactivation (τ h1, τ h2). L860F showed faster activation time constants τ a than RBIIA, while K859Q was slower for both the activation (τ a) and the inactivation components (τ h1). Similarly, the steady-state inactivation curve of L860F but not K859Q shifted by 9 mV in the hyperpolarizing direction. Thus, the fourth charge in the IIS4 transmembrane segment exerts control over voltage sensitivity and kinetics of activation and may interact with structure that influence other aspects of channel gating.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00374254
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  • 9
    Digitale Medien
    Digitale Medien
    A direct-reading device for measurement of patch-clamp micropipette tip diameters (1990)
    Springer
    Pflügers Archiv 417 (1990), S. 255-258 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Micropipette ; Inner tip diameter ; Electronic device ; Patch clamp
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This paper describes an electronic device for the measurement of the diameter of the tip opening of micropipettes. The device measures the threshold pressure required to produce bubbles from the micropipette submerged in a liquid and displays the tip inner diameter in micrometres. We demonstrate that this technique can be used effectively in a range of liquids of different density, surface tension and viscosity and that the thickness of the glass from which the micropipettes are made does not influence the measurements.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370989
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  • 10
    Digitale Medien
    Digitale Medien
    Rats become acutely tolerant to cathine after amphetamine or cathinone administration (1990)
    Springer
    Psychopharmacology 101 (1990), S. 126-131 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Cathinone ; Amphetamine ; Cathine ; Drug discrimination ; Dopamine ; CGS 10746B
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kgd-amphetamine or 0.8 mg/kgl-cathinone to generalize to 2.4–6.0 mg/kg of the active cathinone metabolited-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n=6) trained with cathinone (ED50=3.03 mg/kg) and in rats (n=8) trained with amphetamine (ED50=2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02253729
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