ISSN:
1432-0533
Keywords:
Acquired immune deficiency syndrome (AIDS)
;
Cerebral cortex
;
Dementia
;
Morphometry
;
Neuronalloss
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Neurons of Area 11 in the fronto-orbital cortex of 18 unselected AIDS brains are analyzed by means of stereology. Neurological abnormalities including dementing symptoms were described in eight patients. Neuropathology diagnosed human immunodeficiency virus (HIV)-specific changes in four, and diffuse poliodystrophy in eight brains. The majority (71.4%) of these brains was immunoreactive for HIV antigens when tested by immunocytochemistry. A significant loss of neurons is found as compared to normal controls. Neuronal density in AIDS brains is reduced by 18%, and the perikaryon volume fractions is reduced by 31%. Although only speculation on pathogenesis of this neuronal loss is possible at present, it may represent a part of the pathomorphological substrate of AIDS-related dementia. Moreover, it confirms by quantitative means damage to the cerebral cortex in AIDS which has been described only qualitatively as diffuse poliodystrophy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00294228
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