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  • 1
    Electronic Resource
    Electronic Resource
    Human cytomegalovirus (HCMV)-specific immunoglobulin E as a serologic marker for HCMV infection in immunocompromised patients (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 497-502 
    Details
    ISSN: 1432-1440
    Keywords: Primary human cytomegalovirus infection ; IgE antibody capture enzyme-linked immunosorbent assay ; Renal transplant recipients ; Acquired immunodeficiency syndrome patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An antibody capture assay using an enzyme-linked human cytomegalovirus (HCMV) antigen for the detection of specific immunoglobulin E (IgE) was established. IgG, M, and E responses to HCMV were studied in 497 sera obtained from 44 renal transplant recipients and 51 acquired immunodeficiency syndrome (AIDS) patients. The results were compared with those obtained from 58 HCMV-seropositive healthy individuals. HCMV-specific IgE was detected in 11 (91.7%) renal transplant recipients with primary HCMV infection. In contrast, antibodies of the IgG and IgM classes were detected in only 6 (50.0%) of these patients. Specific IgE was detected in 10 (90.9%) out of 11 renal allograft recipients suffering from secondary HCMV infection. Significant IgG titer rises and IgM were detected in 2 (18.2%) and 6 (54.6%) of these patients, respectively. IgG titer rises and IgM and IgE antibodies were seen in 5 (12.2%), 1 (2.4%) and 18 (43.9%) AIDS patients respectively. All healthy immunocompetent HCMV-seropositive individuals were tested IgE negative. The results obtained in our study indicate that IgE against HCMV is a more reliable serologic marker for primary and secondary HCMV infection than IgM in immunocompromised individuals, especially in organ transplant recipients, since it is not affected by the prophylactic application of HCMV hyperimmune globulin preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00210231
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  • 2
    Electronic Resource
    Electronic Resource
    Übertragbare spongiforme Encephalopathien: die Creutzfeldt-Jakob-Krankheit (1998)
    Springer
    Der Chirurg 69 (1998), S. 511-521 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Transmissible spongiform encephalopathies (TSE) ; Bovine spongiform encephalopathy (BSE) ; New variant Creutzfeldt-Jakob disease (nvCJD) ; Human TSE ; epidemiology ; pathogenesis ; etiology. ; Schlüsselwörter: TSE ; BSE ; Creutzfeldt-Jakob-Krankheit ; neue Variante ; menschliche TSE (Epidemiologie ; Pathogenese ; Ätiologie).
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Verschiedene Krankheiten aus dem Kreis der sog. übertragbaren („transmissible“) spongiformen Encephalopathien (TSE) sind beim Menschen und im Tierreich bekannt. Doch erst in jüngster Zeit sind die TSE durch die BSE-Epidemie (BSE = bovine spongiforme Encephalopathie) und die Beschreibung der wahrscheinlich damit zusammenhängenden neuen Variante der Creutzfeldt-Jakob-Krankheit (nvCJK) ins Bewußtsein der (Fach-)Öffentlichkeit gerückt. Über die Natur der zugrundeliegenden Erreger wird nach wie vor gestritten; keines der vorgeschlagenen Konzepte (Prionen, Viren) vermag alle Aspekte befriedigend zu erklären. Fest steht jedoch eine genetische Komponente bei Infektionsempfänglichkeit und Krankheitsentwicklung sowie die Übertragbarkeit auch über Artschranken hinweg. Diese Arbeit gibt einen Überblick über erste Ergebnisse der in letzter Zeit intensiver betriebenen Grundlagenforschung sowie über jüngste Entwicklungen, sowohl was den Stand der (Früh-)Diagnostik in vivo anbelangt als auch den Ausschluß von möglichen (auch iatrogenen) Übertragungswegen.
    Notes: Summary. Different diseases of the transmissible spongiform encephalopathy (TSE) group are known to affect humans and various animals. Owing to the bovine spongiform encephalopathy (BSE) epidemic and the description of the new variant of Creutzfeldt-Jakob disease (nvCJD), which is probably linked to BSE, TSE received much attention. The nature of the causative agent is still disputed; none of the proposed concepts (prions, viruses) can explain all features. It is clear, however, that there is a genetic component in susceptibility to infection and in development of disease and that transmission may cross the species barrier. This paper gives an overview of the first results and latest developments of basic TSE research that has focused on in vivo early diagnosis and the prevention of possible (also iatrogenic) transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050448
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    Paper (German National Licenses)
    Fulltext
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