ISSN:
1573-739X
Keywords:
Administration, endobronchial
;
Administration, intravenous
;
Atropine
;
Pharmacokinetics
;
Radioligand assay
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01956512
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