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  • 1
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Pseudomonas aeruginosa ; Sepsis ; Adrenale hämorrhagische Nekrose ; Neugeborenes ; Key words Pseudomonas aeruginosa ; Sepsis ; Adrenal haemorrhagic necrosis ; Neonate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Acute haemorrhages of the adrenals in a septicemia with meningococci have been a well-known complication. They have also been described in neonates for septicemia due to E. coli, staphylococci and streptococci. Case: We observed a fulminant lethal septic disease with bilateral acute haemorrhagic necrosis in a 14-day-old preterm infant. Pseudomonas aeruginosa were isolated from blood culture. Discussion: This is the first report on Waterhouse-Friderichsen-syndrome triggered by Pseudomonas aeruginosa.
    Notes: Zusammenfassung Hintergrund: Akute Nebennierenblutungen sind bekannte Komplikationen der Meningokokkensepsis. Sie wurden auch bei Neonaten mit Sepsis durch E. coli, Staphylokokken und Streptokokken beschrieben. Fall: Wir beobachteten eine fulminante letal verlaufende Sepsis mit bilateraler hämorrhagischer Nekrose der Nebennieren bei einem 14 Tage alten Frühgeborenen. In der Blutkultur konnte Pseudomonas aeruginosa isoliert werden. Diskussion: Erstmals wird über ein Waterhouse-Friderichsen-Syndrom berichtet, das durch Pseudomonas aeruginosa ausgelöst wurde.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0878
    Keywords: Serotonin (5HT) ; Hibernation ; Computerized image analysis ; Raphe nuclei ; Suprachiasmatic nucleus ; Spermophilus richardsonii (Rodentia)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In the suprachiasmatic nucleus (NSC) of hibernating and non-hibernating ground squirrels, the distribution of serotonin-immunoreactive (5HT-IR) fibers was studied by the use of the peroxidase-antiperoxidase technique. The cytology of perikarya giving rise to these suprachiasmatic 5HT-IR fibers was investigated in the anterior raphe nuclei. Differences in the immunoreactivity of suprachiasmatic fibers between hibernating and non-hibernating ground squirrels were determined by digital image analysis. The cellular activity was determined densitometrically after RNA-staining in anterior raphe neurons and suprachiasmatic perikarya. Abundant 5HT-IR fibers were observed in the medial and ventromedial portions of the NSC. Frequently, the fibers were found in close contact with perikarya of suprachiasmatic neurons. The central portion of the nucleus and the surrounding hypothalamic areas contained only a few scattered 5HT-IR fibers. Inside the raphe nuclei, 5HT-IR fibers and perikarya formed a dense network. In hibernating ground squirrels, the immunoreactivity to serotonin was approximately 45% higher than in non-hibernating controls. This difference is in accordance with signs of higher neuronal activity (40% higher RNA-content, 20% larger cell nuclei) in 5HT-IR perikarya of the raphe nucleus and the persisting activity of the NSC during hibernation; the activity of other brain regions dropped conspicuously in torpid animals.
    Type of Medium: Electronic Resource
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