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  • 1
    Electronic Resource
    Electronic Resource
    Gene amplifications in advanced-stage human prostate cancer (1995)
    Springer
    Urological research 22 (1995), S. 343-347 
    Details
    ISSN: 1434-0879
    Keywords: Prostate carcinoma ; Prostatic neoplasms ; Gene amplifications ; Oncogenes ; Advanced-stage disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Gene amplification is a model of proto-oncogene alterations occasionally observed in human tumors. This amplification can, in some cases, have prognostic value (N-myc in neuroblastoma, c-erbB2 and int-2 in breast cancer, etc.). Amplifications of the proto-oncogenes c-myc, c-erbB2 and int-2 have not yet been report in prostate adenocarcinoma, which, like breast cancer, is hormone dependent. We sought amplifications of these three proto-oncogenes by means of Southern blotting in 15 human prostate adenocarcinoma specimens, most of which were advanced (7 stage C and 6 stage D1 or D2). We confirmed the lack of c-myc and c-erbB2 amplification, regardless of the stage, in contrast to the case of breast cancer. Int-2 amplification was observed in one advanced tumor with bone metastases, out of a total of six stage D tumors. The precise frequency of int-2 amplification and its role in prostate carcinogenesis remain to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296872
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Captopril induces correction of postrenal transplant erythremia (1990)
    Springer
    Transplant international 3 (1990), S. 222-225 
    Details
    ISSN: 1432-2277
    Keywords: Erythremia, post-transplantation ; Captopril, erythremia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Kidney transplant patients may develop post-transplant erythremia (PTE), and in order to avoid thromboembolism venesection, anticoagulation and native kidney removal have been suggested. We propose captopril as an alternative therapy for PTE. Seven hypertensive PTE patients, aged 42±10 years with stable renal function, were investigated to exclude primary or secondary polycythemia. All patients manifested true erythrocytosis [red blood cells (RBC) mass〉20% of predicted level] with concomitant increases in hematocrit and hemoglobin levels. Captopril was introduced in gradually increasing doses up to 75 mg/day under careful monitoring of blood pressure and renal function. Weekly follow-up was arranged to evaluate drug efficacy. After captopril, a significant reduction with normalization of the RBC mass (42±4 vs 31±5 ml/kg; P〈0.005) was observed. The RBC counts and hematocrit and hemoglobin levels also decreased. One patient had recurrent erythrocytosis after captopril withdrawal. Captopril may be a simple, effective, and non aggressive treatment for postrenal transplant erythremia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366970
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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