ISSN:
1435-1463
Schlagwort(e):
Age-related change
;
dopamine receptor
;
G protein
;
mRNA
;
L-DOPA responsiveness
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50–105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein casccade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01271245
Permalink