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  • 1
    ISSN: 1432-0533
    Keywords: Senile dementia of Alzheimer's type ; Alzheimer's disease ; Pick's disease ; Laminar neuronal loss ; Limbic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 71 (1986), S. 344-346 
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Lewy body ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case is reported which revealed not only clinical and neuropathological features of progressive supranuclear palsy, but also the presence of large numbers of Lewy bodies in the brain stem nuclei and cerebral cortex. This case seems to be progressive supranuclear palsy with Lewy bodies distributed as in Parkinson's disease. Such case has not been previously reported.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0533
    Keywords: Hemiconvulsion ; Unilateral hemispheric change ; Neuronal loss ; Spongy state ; Creutzfeldt-Jakob disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 77-year-old man suffered intermittent hemiconvulsions of unknown etiology on the left side for a period of about 5 weeks. At the autopsy, there was marked neuronal loss, severe proliferation of astrocytes and spongiform changes in the right cerebral cortex. The cerebral white matter showed loosening with astroglial proliferation in areas on the same side. These neuropathological changes were slight or absent in the left cerebral hemisphere. Histopathological changes were similar to those seen in unilateral Creutzfeldt-Jakob disease (CJD). Although unilateral CJD can not be ruled out, these unilateral hemispheric changes might be induced by intermittent hemiconvulsions.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    General and Comparative Endocrinology 78 (1990), S. 231-241 
    ISSN: 0016-6480
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1463
    Keywords: Age-related change ; dopamine receptor ; G protein ; mRNA ; L-DOPA responsiveness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the cause of the age-related decrease in the responsiveness to L-DOPA seen in parkinsonian patients, we studied age-related changes in the mRNA levels of dopamine receptors (D1, D2) and of G proteins (Gs, Gi, Go) in 22 control human brains aged 50–105 years. Neither the mRNA levels of dopamine receptors or of the G proteins changed with age. Another factor in the receptor-G protein casccade, such as guanine nucleotide binding, may cause the age-related decrease in responsiveness.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neural transmission 103 (1996), S. 1177-1185 
    ISSN: 1435-1463
    Keywords: Levodopa ; pharmacokinetics ; absorption ; wearing-off ; LNAA system ; Parkinson's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of the chronic administration of levodopa on its peripheral pharmacokinetics and the contribution of the pharmacokinetics to the pathogenesis of the wearing-off phenomenon are re-evaluated. The concentration of plasma levodopa and clinical symptoms were determined 4 hours after oral levodopa (levodopa 100 mg+benserazide 25 mg) administration on 55 parkinsonian patients. Long-term levodopa therapy markedly increased the peak levodopa concentration (Cmax) and the area under the time-concentration curve (AUC); whereas, it decreased time to the peak concentration (Tmax) and the elimination half-life (T1/2). These results suggest that longterm levodopa therapy accelerates the absorption of levodopa. The wearingoff group (n=23), however, had a markedly higher Cmax and AUC, and a shorter Tmax and T1/2 than the stable group (n=32). We speculate that the clinical expression of “stable” or “wearing-off” depends on the absorption of levodopa as well as the presynaptic terminal and post synaptic receptors.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Materials and structures 23 (1990), S. 305-315 
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract As part of the work of RILEM T/C83-CUS, a statistical survey on mechanical properties of recent Japanese steels was performed on the basis of mill sheet data collected from six major mill makers of Japan. As a major result, wide scatter bands of yield point strength were found; this caused higher yield ratios of supplied steels than those based on the specified lower limits of yield strength and tensile strength. A high yield ratio is not preferable for ductility design of steel yield strength and tensile strength. A high yield ratio is not preferable for ductility design of steel structures. Thus, the upper limit of yield strength or yield ratio should be specified for such design use.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1459
    Keywords: Cerebrovascular disease ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einem Autopsiematerial von 87 Fällen werden die Ergebnisse der Computertomographie einerseits und der neuropathologischen Untersuchung andererseits bei vasculären cerebralen Erkrankungen verglichen. Im besonderen werden die Größe und Lokalisation der Schädigungen, die Erfahrung der Beurteiler und technische Verbesserungen des CT berücksichtigt. Kleine Infarkte von weniger als 5 mm Durchmesser waren außerordentlich schwer im CT nachzuweisen. Dies war vorwiegend auf die technischen Grenzen des CT zurückzuführen. Auch die korrekte Diagnose von mittelgroßen Infarzierungen war oft schwierig. Dies war vorwiegend auf die anatomische Lokalisation der Läsionen zurückzuführen, nämlich die Nachbarschaft zu erweiterten und tiefen Sulci, die Lage in der periventriculären weißen Substanz sowie innerhalb von Strukturen der hinteren Schädelgrube. Große Infarkte konnten im CT leicht nachgewiesen werden mit Ausnahme der frühen Phase oder bei hämorrhagischer Infarzierung. Eine verbesserte Treffsicherheit der CT Diagnostik für kleine und mittlere Infarzierungen konnte nicht durch eine zunehmende Erfahrung der Beurteiler, sondern lediglich durch eine technische Verbesserung der Computertomographie erreicht werden.
    Notes: Summary The findings on computed tomography (CT) and neuropathological examinations were correlated in 87 autopsied cases of cerebrovascular disease with regard to the size and location of lesions, experience of reviewers, and improvement in CT quality. Small infarctions less than 5 mm were very difficult to detect accurately on CT. This was largely because of the limitations in the efficiency of the CT scanner. Accurate diagnosis of medium sized infarctions was also often difficult. This was mainly due to the anatomical location of lesions, the confluence of deep and widened sulci, periventricular white matter, and structures in the posterior fossa. Large infections could be visualized easily on CT, except in their early periods or in cases with hemorrhagic infarctions. The improved accuracy of CT diagnosis for small and medium sized infarctions could not be attained by the experience of reviewers, but was only possible by instrumental improvement of CT quality.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1459
    Keywords: Anticoagulant therapy ; Non-valvular atrial fibrillation ; Cerebral embolism ; Recurrent stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the prevention of recurrent embolic stroke, 23 elderly patients with non-valvular atrial fibrillation (NVAF) were treated with oral anticoagulants (warfarin) during a mean period of 3.8 years. Only one patient suffered recurrent embolism, and another had acute myocardial infarction. There was no cerebral haemorrhage during the treatment. In an untreated control group (from an autopsy series), recurrent embolic strokes occurred in 18 of 70 NVAF patients (26%) during a mean period of 1.3 years. Long-term anticoagulant therapy appears to be effective in the prevention of recurrent embolic stroke in elderly patients with NVAF.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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