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  • 1995-1999  (2)
  • 1955-1959
  • Aging effects  (1)
  • Anti-Myeloperoxidase Antibody  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Age-related changes in the compound action potentials of the eighth nerve in guinea pigs (1997)
    Springer
    European archives of oto-rhino-laryngology and head & neck 254 (1997), S. 145-149 
    Details
    ISSN: 1434-4726
    Keywords: Eighth nerve compound action potential ; Aging effects ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The eighth nerve compound action potential (CAP) in 95 guinea pigs was measured using click stimuli to investigate age-related changes in their neural auditory thresholds. The animals were separated into three groups: group A (n = 43, 86 ears; 2–4 months old); group B (n = 29; 58 ears, 13–15 months old); and group C (n = 23; 46 ears, 23–25 months old). With increasing age, a gradual elevation of CAP thresholds was clearly seen among the three groups. The negative peak (N1) latencies of the CAP were prolonged, and the N1 amplitudes of the CAP decreased. There were significant differences in N1 latencies among the three groups and in N1 amplitudes between groups A and B, and between groups A and C. However, the rate of decline of the thresholds as well as the input-output function curves of the CAP varied in some of the oldest animals, suggesting that there were some individual differences in degenerative aging processes of the auditory system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02471279
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  • 2
    Electronic Resource
    Electronic Resource
    Anti-neutrophil cytoplasmic antibody in patients with systemic lupus erythematosus is unrelated to clinical features (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 70-75 
    Details
    ISSN: 1434-9949
    Keywords: Disease Activity Index ; Anti-Myeloperoxidase Antibody ; Anti-Lactoferrin Antibody ; Lupus Nephritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate the incidence, the specificity and clinical significance of positivity for serum anti-neutrophil cytoplasmic antibody (ANCA) in 31 patients with systemic lupus erythematosus (SLE), the indirect immunofluorescence (IIF) technique and enzyme-linked immunosorbent assay (ELISA) were used to measure ANCA. Purified myeloperoxidase (MPO), lactoferrin (LF), cathepsin-G (CTG) and elastase (HLE) served as ANCA antigens for ELISA. Thirteen (42%) of the 31 SLE patients showed positivity for perinuclear, but not cytoplasmic, ANCA by IIF. Five of 31 sera were positive for MPO, 10 for LF, 1 for CTG and 0 for HLE by ELISA. Patients positive for ANCA had a higher score of SLE disease activity index (SLEDAI) than those without ANCA. There was no correlation between ANCA positivity, clinical manifestations, or organic involvement. While the ANCA in patients with SLE reflected disease activity, it was unrelated to organic involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02238766
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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