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  • 1
    Electronic Resource
    Electronic Resource
    Cyclophosphamide-resistant Yoshida ascites tumor cells and their cross resistance to some alkylating agents (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 257-263 
    Details
    ISSN: 1432-1335
    Keywords: Yoshida ascites tumor ; Cyclophosphamide ; Alkylating agents ; Resistance and cross resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A cyclophosphamide-resistant subline of a Yoshida ascites tumor was developed by giving increasing doses of the drug after transplantation. The effect of several alkylating agents on the cell proliferation of both the sensitive and resistant cell line was compared establishing dose response curves and D50 values. The developed subline revealed a 260 fold resistance to cyclophosphamide. It was completely cross-resistant to hydroperoxycyclophosphamide, whereas for triaziquone, N-oxide-mustard, and N-methyl-mustard only a partial cross resistance existed. These results give further evidence that cyclophosphamide and hydroperoxycyclophosphamide have the same mechanism of action. Regarding the other alkylating agents the results demonstrate differences concerning either the molecular mode of action or protecting effects. A decreased activation or uptake of substance is probably not the base for resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419285
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  • 2
    Electronic Resource
    Electronic Resource
    Untersuchungen zur radikalischen Copolymerisation von Acrylnitril mit α-Olefinen. 5. Mitt. Bestimmung der r-Werte am System Acrylnitril/Allylbenzol4. Mitt.: siche [8]Teil der Dissertation von H. S. Trang, Technische Universität Dresden, Sektion Chemie, 1978Herrn Professor Dr. Vasilij Vladimirovič Koršak zur Vollendung des 70. Lebensjahres gewidmet. (1979)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 30 (1979), S. 98-102 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The r-values of the monomer pair acrylonitrile/allylbenzene in the radical bulk and solution polymerization, using hexamethylphosphoric acid triamide, dimethylsulfoxide, γ-butyrolactone, ethylene carbonate and nitromethane as solvents, have been determind. A copolymerization equation is derived, considering the degradative chain transfer, associate formation and solvent effect, by which the deviations from the Mayo-Lewis concept and the solvent effects can be explained.
    Notes: Die r-Werte des Monomerpaares Acrylnitril/Allylbenzol wurden bei der radikalischen Copolymerisation in Substanz bzw. in den Lösungsmitteln Hexamethylphosphorsäuretriamid, Dimethylsulfoxid, γ-Butyrolacton, Ethylencarbonat und Nitromethan bestimmt. Unter Berücksichtigung der degradativen Kettenübertragung, der Assoziatbildung und des Lösungsmitteleinflusses wurde eine Copolymerisationsgleichung abgeleitet, mit deren Hilfe die Abweichung vom Mayo-Lewis-Modell und Lösungsmitteleffekte interpretierbar sind.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1979.010300206
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen zur radikalischen Copolymerisation von Acrylnitril mit α-Olefinen. 6. Mitt. Zur Assoziatbildung von Allybenzolsiehe 5. Mitt. [1] (1979)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 30 (1979), S. 409-411 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: In order to investigate the deviation of the copolymerization of acrylonitrile with allyl benzene from the Mayo-Lewis model caused by association the temperature-dependence of the r-values in different solvents and at different monomer ratios was determined. Independent comparison is achieved by 1H and 13C-NMR spectra of allyl benzene in tetrachloromethane and nitromethane.
    Notes: Zur Untersuchung der Abweichung vom MAYO-LEWIS-Modell bei der Acrylnitril-Allylbenzol-Copolymerisation durch Assoziatbildung wurde die Temperaturabhängigkeit der r-Werte in verschiedenen Lösungsmitteln und bei unterschiedlichen Monomermischungsverhältnissen bestimmt. Zum unabhängigen Vergleich dienten 1H- und 13C-NMR-Spektren des Allylbenzols in Tetrachlormethan und Nitromethan.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1979.010300706
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    Paper (German National Licenses)
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