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  • Alzheimer's disease  (2)
  • Atrophic auto-immune thyroiditis  (1)
  • D1S80  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with alzheimer's disease (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 94-97 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Alzheimer's disease ; brain ; proteases ; kallikrein ; prolyl endopeptidase
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10−7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01955428
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  • 2
    Digitale Medien
    Digitale Medien
    Deficiency of fibrinolytic enzyme activities in the serum of patients with Alzheimer-type dementia (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 656-659 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Alzheimer's disease ; patients' serum ; clotting system ; fibrinolytic system ; plasmin ; urokinase ; thrombin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Previously we reported that there is a kallikrein deficiency in the cerebral tissue of patients with Alzheimer-type dementia. The present study was performed to investigate protease changes in the serum of these patients. The results showed that the kallikrein activity was normal, but that the activities of plasmin and urokinase were significantly low. The present findings indicate a derangement in the clotting and fibrinolytic systems in Alzheimer patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02118312
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  • 3
    Digitale Medien
    Digitale Medien
    Comparison of atrophic and goitrous auto-immune thyroiditis in children: Clinical, laboratory and TSH-receptor antibody studies (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 529-533 
    Details
    ISSN: 1432-1076
    Schlagwort(e): Atrophic auto-immune thyroiditis ; Goitrous auto-immune thyroiditis ; TSH-binding inhibitor immunoglobulins ; Thyroid stimulation blocking antibodies ; TSH receptor antibodies
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We studied the clinical features, laboratory and thyroid functions and thyrotropin (TSH)-receptor and thyroid-stimulation antibodies in 21 patients with atrophic auto-immune thyroiditis (AAT) and 48 patients with goitrous auto-immune thyroiditis (GAT) of childhood onset. The clinical features of patient with AAT were cessation of growth and obesity, while asymptomatic enlargement of the thyroid gland was the sole symptom in most patients with GAT. Although the ages at diagnosis were comparable in both groups, the estimated ages at onset were much lower in patients with AAT than in those with GAT. Patients with AAT exhibited more severe hypothyroidism when evaluated by serum thyroxine (T4), tri-iodothyronine (T3), TSH, cholesterol levels and basal metabolic rates. The 24h123I-thyroidal uptake was significantly lower in patients with AAT than in those with GAT. None of the 19 patients with AAT possessed TSH-binding inhibitor immunoglobulins (TBII). On the other hand, 3 of the 32 GAT patients tested, possessed weak to potent TBII activities. Three TBII-positive patients with GAT also possessed thyroid-stimulation blocking antibodies. These findings suggest that: 1. Pathogenesis of AAT in children whose onset of hypothyroidism was before puberty is not due to TSH-receptor blocking antibodies, which are often found in patients with AAT of postpubertal onset. 2. AAT in children is considered not to be due to the later stage of GAT. 3. Some patients with GAT possessed TSH-receptor blocking antibodies. The aetiology and pathogenesis of AAT in children have yet to be elucidated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01957685
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  • 4
    Digitale Medien
    Digitale Medien
    Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila (1998)
    Springer
    International journal of legal medicine 111 (1998), S. 224-226 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Key words Population study ; HUMFES ; HUMVWA ; HUMF13A01 ; D1S80 ; Philippines
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Notizen: Abstract Allele frequency distributions at the short tandem repeat (STR) loci HUMVWA, HUMFES, HUMF13A01 and of the variable number of tandem repeat (VNTR) locus D1S80 were determined in a Filipino population from Metro Manila (103 individuals) by use of the polymerase chain reaction (PCR) followed by polyacrylamide gel electrophoresis (PAGE). The exact test demonstrated that all four loci had no deviations from Hardy-Weinberg equilibrium (HWE) with the only reservation that the exact test p-value for F13A01 is weak. The discriminating power is 0.82 for D1S80, and the expected exclusion chance is 0.85 for F13A01, 0.83 for FES, and 0.93 for VWA. The observed heterozygosity rates are 0.63 for D1S80, 0.66 for F13A01, 0.67 for FES, and 0.80 for VWA. The exact test for independance between all loci gave a p-value of 0.0195. This is the first time that Filipino population data of DNA loci of forensic importance are reported.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004140050157
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