ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The mass spectral properties of four classes of derivatives of thyronine are discussed (oxazolidinone, O-methyl oxazolidinone, O-acetyl oxazolidinone and N,O-diheptafluorobutyryl methyl ester). An assay for thyronine in human urine is described based on the N,O-diheptafluorobutyryl methyl ester. Results of To excretion in euthyroid humans were compared with those obtained previously using an assay based on the O-acetyl oxazolidinone derivative. Patients with frank hyperthyroidism had significantly higher To excretion than euthyroid subjects (2α 〈 0.002) and hypothyroid patients lower To excretions than enthyroid subjects (2α 〈 0.002). Some overlap between the two pathological ranges and the normal euthyroid range was evident.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200110411
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