ISSN:
1434-9949
Keywords:
Sulphasalazine
;
Ankylosing Spondylitis
;
Disease Modifying Antirheumatic Drug
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In a 12-month double-blind placebo-controlled trial, the effect of sulphasalazine was studied in 40 patients with ankylosing spondylitis. The treatment group showed significant improvement in pain, stiffness, sleep disturbance (p〈0.05), finger/floor distance, erythrocyte sedimentation rate, C-reactive protein, orosomucoid and IgA levels (p〈0.01). There was improvement in sleep disturbance (p〈0.05), finger/floor distance and erythrocyte sedimentation rate (p〈0.01) in the placebo group. Sulphasalazine did not retard radiological progression as measured either by plain X-ray or computerised tomographic scans. Multiple analysis of variance did not show a significant difference in disease activity indicators between the 2 groups.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02208032
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