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  • 1
    Electronic Resource
    Electronic Resource
    Osmosin: its effect on plasma and synovial fluid kinetics of indomethacin (1985)
    Springer
    European journal of clinical pharmacology 27 (1985), S. 689-691 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin ; Osmosin ; plasma and synovial fluid ; polyarthritis ; inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary ‘Osmosin’ (sodium indomethacin trihydrate, now withdrawn) produced a constant rate of release of indomethacin into the gut. Paired plasma and synovial fluid samples were obtained at regular intervals following a single dose of ‘Osmosin’ (19 patients) and after continuous daily dosing (15 patients). Indomethacin is rapidly absorbed and plasma concentrations maintained in the range 0.3 to 0.6 µg/ml after the first 4 h. Equilibrium between plasma and synovial fluid occurs, with SF/plasma ratios 0.74 to 0.82 12–24 h after a single dose and up to 0.96 thereafter. The indomethacin synovial fluid/plasma profile is changed by Osmosin from the pattern of a short half-life drug to the pattern typical of a long half-life drug. Results from serial samples obtained by use of indwelling cannulae (in vein and knee joint) show close agreement with our single paired sampling technique. Our method may have theoretical disadvantages but it has many practical advantages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547050
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  • 2
    Electronic Resource
    Electronic Resource
    Plasma and synovial fluid concentrations of diclofenac sodium and its hydroxylated metabolites during once-daily administration of a 100 mg slow-release formulation (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 469-472 
    Details
    ISSN: 1432-1041
    Keywords: diclofenac sodium ; slow-release formulation ; plasma and synovial fluid concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Plasma and knee joint synovial fluid (SF) concentration of diclofenac sodium and its hydroxylated metabolites were measured after chronic dosing with the 100 mg polymer matrix formulation. Peak concentrations were reached in plasma and SF roughly after administration. Plasma concentrations then fell rapidly, but concentrations in SF were maintained for up to 25 h. The active metabolite was present in both fluids throughout the study period. The slow-release form showed a longer plasma/SF equilibration time than the conventional tablet had in a previous study. Prostaglandin E1 and F2a concentrations were lower in the early post-dose period but did not correlate with drug concentrations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613526
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    ELISA assays for IgM and IgG rheumatoid factors: Their clinical correlations during therapy with slow-acting anti-rheumatic drugs (1987)
    Springer
    Clinical rheumatology 6 (1987), S. 358-368 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A longitudinal study of changes in rheumatoid factor levels and their correlations with other clinical and laboratory assessment of disease activity followed 45 rheumatoid arthritis patients during 12 months continuous therapy with gold and penicillamine. Rheumatoid factors were measured by the titred latex assay and by ELISA assays for IgM and IgG rheumatoid factor. The IgM ELISA assay correlated strongly with the titred latex assay and weakly with the IgG rheumatoid factor assay at 0, 6 and 12 months. All showed significant falls with treatment, and ELISA assays were not more sensitive indicators than the latex assay. Correlations of initial rheumatoid factor levels by all 3 assays to 34 other clinical and laboratory assessments showed that only a small number of weak correlations existed; there were more at 6 and 12 months, but still not many. Changes in rheumatoid factor levels over 0–6 months showed no significant correlation to changes in other variables. There were no more correlations with ELISA assays than with titred latex rheumatoid factor. We conclude that ELISA rheumatoid factor assays have no clinically relevant advantage over the titred latex assay when following rheumatoid patients treated with gold or penicillamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02206834
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  • 4
    Electronic Resource
    Electronic Resource
    Right-sided endocarditis complicating prolonged central venous catheterisation (1981)
    Springer
    Intensive care medicine 7 (1981), S. 245-246 
    Details
    ISSN: 1432-1238
    Keywords: Atrial endocarditis ; Central venous catheterisation ; Polyethylene and silastic catheters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three cases of right atrial endocarditis complicating central venous catheterisation are described. Diagnosis was difficult, the patients were toxic from their primary disease, cardiac murmurs were absent and there were no classical features of endocarditis. With greater use of central catheters this complication may be expected to increase. Strict asepsis and clinical suspicion must be rigorously maintained. We suggest that silastic catheters should be used if a central line is required for longer than 72 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01702628
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Intra-articular steroids: Confounder of clinical trials (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 38-42 
    Details
    ISSN: 1434-9949
    Keywords: Intra-Articular Steroids ; ESR ; C-Reactive Protein ; Rheumatoid Arthritis ; Drug Efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of intra-articular (i-a) steroid injection on ESR and C-reactive protein (CRP) in rheumatoid arthritis (RA) was investigated. One week following injection of 1 or 2 knees there was a significant fall in ESR (p〈0.0001) and CRP (p〈0.01) in a cohort of 20 RA patients. The mean drop for both ESR and CRP was 46%. This effect lasted over a variable period up to 6 months. A survey of 50 published drug efficacy studies in RA revealed that, while 44 used ESR and 20 CRP as efficacy measures, 37 neither excluded nor recorded i-a steroid injections during the study. Steroid injections were excluded in 8 studies and recorded in 5, being used as an outcome measure in 2 of these. It is recommended that the frequency with which i-a injections are used in drug efficacy studies is reported and that they are avoided in the 3 months preceding an outcome measurement if ESR or CRP are being used as outcome measures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208031
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  • 6
    Electronic Resource
    Electronic Resource
    Human parvovirus B19 and rheumatoid arthritis (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 548-550 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Infection ; Parvovirus ; Early Synovitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human parvovirus B19 infections have been linked with the development of a short-lived symmetrical polyarthritis and, rarely, a more persistent arthritis. We prospectively looked for serological evidence of recent B19 infection in 25 early synovitis patients presenting within 12 weeks of symptom onset and compared them with 21 controls seen over the same time period. None of the control patients had evidence of recent B19 infection while 3 of the early synovitis patients had raised IgM anti-B19 antibody levels. Two had a transient arthritis and 1 developed persistent seropositive rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02283117
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  • 7
    Electronic Resource
    Electronic Resource
    Capillaritis : A manifestation of rheumatoid disease (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 53-56 
    Details
    ISSN: 1434-9949
    Keywords: Capillaritis ; Vasculitis ; Rheumatoid Arthritis ; Disease Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We present seven cases of capillaritis arising in patients with rheumatoid arthritis and suggest that it is primarily related to disease activity and not drugs. In the majority, the rash resolved spontaneously with the use of a topical steroid to treat the symptom of itch.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231559
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  • 8
    Electronic Resource
    Electronic Resource
    Synovial sarcoma manifesting as a single joint flare in rheumatoid arthritis (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 89-92 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Monoarthritis ; Synovial Sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 69-year-old female recently diagnosed as suffering from rheumatoid arthritis presented with a general flare-up of disease including a swollen left ankle. Investigation revealed the swelling to be due to a synovial sarcoma. This unusual cause should be considered in all cases of local joint flares in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231566
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  • 9
    Electronic Resource
    Electronic Resource
    Interleukin-2 production in early rheumatoid arthritis (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 285-286 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231550
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  • 10
    Electronic Resource
    Electronic Resource
    Combination therapy for rheumatoid arthritis and drug-induced systemic lupus erythematosus (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 522-524 
    Details
    ISSN: 1434-9949
    Keywords: Drug-induced SLE ; Combination Therapy ; Rheumatoid Arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Development of drug-induced systemic lupus erythematosus (SLE) is an uncommon complication of the use of D-penicillamine and sulphasalazine. We report two cases of patients with rheumatoid arthritis (RA) who developed symptoms and signs of SLE and suggest that increasing use of these two agents as combination therapy in RA may cause an additive risk to the occurrence of this complication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242956
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