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  • 1
    Electronic Resource
    Electronic Resource
    The specificity of antiglobulin autoantibodies in patients with primary Sjögren's syndrome (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 501-508 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Factor ; Anti-Fab Antibody ; Primary Sjögren's Syndrome ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antiglobulin autoantibodies have already been demonstrated in the sera of patients with primary Sjögren's syndrome (primary SS). In our study, the specificity of primary SS antiglobulins for different regions IgG molecules was examined by employing both direct binding and competitive inhibition enzymelinked immunosorbent assay. We found that a considerable amount of total antiglobulins in primary SS was specific for the Fab portion, although the remainder was specific for the Fc portion, namely rheumatoid factor (RF). In contrast, most of the antiglobulins in RA were specific for the Fc portion of IgG. These results indicate that in primary SS, antiglobulins directed against epitopes different from those of RF are produced. These antiglobulins may prove to have a different role in primary SS than that ascribed to RF in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030512
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phase-dependent shift of free-running human circadian rhythms in response to a single bright pulse (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 1205-1207 
    Details
    ISSN: 1420-9071
    Keywords: Human circadian rhythm ; bright light pulse ; phase-shift ; temporal isolation ; phase response curve
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Responsiveness of free-running human circadian rhythms to a single pulse of bright light was examined in a temporal isolation unit. Bright light (5000 lx) of either 3 or 6 h duration, applied during the early subjective day, produced phase-advance shifts in both the sleep-wake cycle and the rhythm of rectal temperature; the light pulse had essentially no effect on the phase of the circadian rhythms, when it was introduced during the late subjective day or the early subjective night. The results indicate that bright light can reset the human circadian pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945525
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Entrainment of human circadian rhythms by artificial bright light cycles (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 572-574 
    Details
    ISSN: 1420-9071
    Keywords: Human circadian rhythm ; entrainment ; artificial bright lights ; temporal isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Artificial bright light cycles (LD 8∶16) of about 5000 lux during the light period were applied to two subjects in a temporal isolation unit, who had shown free-running circadian rhythms in sleep-wakefulness and rectal temperature. The circadian rhythms were successfully entrained by the artificial light cycle, but the phase relation of the rhythms to the light cycle was substantially different between the two subjects. The result indicated that the artificial bright lights are able to reset human circadian rhythms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02143589
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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