ISSN:
1432-5233
Keywords:
Anti-myeloperoxidase antibody
;
Polymorphonuclear leucocytes
;
Endothelial cell
;
Intercellular adhesion molecule 1 (ICAM-1)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Anti-myeloperoxidase (anti-MPO) antibodies were detected in 34 of 88 (38%) patients with type 1 diabetes mellitus but in only 3 of 55 (5.7%) healthy subjects and in 4 of 20 patients with autoimmune disease. Specificity of anti-MPO antibodies was assessed by MPO inhibition studies. No relationship was found between the occurrence of anti-MPO and anti-thyroperoxidase antibodies. Levels of soluble intercellular adhesion molecule 1 (ICAM-1) were found to be higher in anti-MPO antibodypositive (n=28, 508±126 ng/ml) than in anti-MPO antibody-negative (n=58, 438±140 ng/ml;P〈0.05) patients. A state of chronic neutrophil activation has been described in diabetes mellitus. As anti-MPO antibodies can stimulate neutrophils to damage endothelial cells in systemic vasculitis, this suggests that a similar mechanism may be operative in the development of diabetic angiopathy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00569418
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