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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mund-, Kiefer- und Gesichtschirurgie 3 (1999), S. S74 
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Vertikale Alveolarkammdistraktion ; Distraktionsimplantate ; Kieferkammatrophie ; Key words Distraction implants ; Vertical distraction ; Alveolar process ; Alveolar ridge atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The masticatory rehabilitation of patients is dependent on the quality and volume of residual jaw bone. Loss of volume caused by tumor-related mandibular ridge resection or age-related atrophies may cause considerable problems. Reconstructive methods using free iliac bone, external tabula, or sandwich plasties are only a few examples of the common surgical treatment modalities. Doing without bone grafts, alveolar ridge augmentation by means of distraction osteogenesis might become a value method to improve the denture-bearing area. A new distraction implant system is shown and its first clinical use reported. Two distraction implants were inserted after an anterior segmental osteotomy. The alveolar ridge was then elevated 1 mm each day until the required augmentation of about 8 mm was achieved. After a latency period for pre-ossification of the callus, the distraction implants were replaced by the endosseous implants. The implant system and the surgical technique are shown, and the results are discussed. We believe that the implant distraction procedure will make useful contribution to the management of masticatory rehabilitation.
    Notes: Zusammenfassung Die kaufunktionelle Rehabilitation eines Patienten ist nicht zuletzt von der Qualität und dem Volumen des vorhandenen Kieferknochens abhängig. Volumenverluste nach tumorbedingten Unterkieferkastenresektionen oder altersabhängige Atrophien können hier erhebliche Probleme bereiten. Ersatzplastiken mit freiem Beckenkamm, Tabula externa oder Sandwich-Plastiken sind nur einige Beispiele für die bislang üblichen chirurgischen Behandlungsverfahren. Unter Verzicht auf Knochentransplantate könnte die Kieferkammaugmentation mit Hilfe der Distraktionsosteogenese hier einen wertvollen Beitrag zur Verbesserung des Prothesenlagers liefern. Es werden ein neues, implantatgestütztes System zur vertikalen Knochendistraktion vorgestellt und über einen ersten klinischen Einsatz anhand einer Einzelfallbeschreibung berichtet. Nach einer anterioren Segmentosteotomie wurden 2 Distraktionsimplantate inseriert, dann der Kieferkamm täglich um 1 mm bis zur gewünschten Augmentation um 8 mm angehoben. Nach einer 4wöchigen Latenzphase zur Frühossifikation des Kallus wurden dann die Distraktionsimplantate durch definitive enossale Implantate ersetzt. Insgesamt hat uns die klinische Anwendung ermutigt, den hier begonnenen Weg fortzusetzen. Implantatsystem und Operationstechnik werden erläutert, die Ergebnisse diskutiert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 352 (1995), S. 520-528 
    ISSN: 1432-1912
    Keywords: Cardiac muscle ; Antiarrhythmic drugs ; Electrophysiology ; Recovery of V maX ; Action potential duration ; Rate-dependent block ; Sodium channels ; Potassium channels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cellular electrophysiological effects of dridocainide (EGIS-3966), a novel class I antiarrhythmic agent, was studied using conventional microelectrode techniques in canine cardiac Purkinje fibres and papillary muscle preparations obtained from humans and guinea-pigs. In each preparation, dridocainide (0.6–2 μmol/l) decreased the maximum velocity of action potential upstroke (Vmax) in a frequency-dependent manner, although marked differences were observed in its effects in Purkinje fibre and ventricular muscle preparations. In canine Purkinje fibres, action potential duration measured at 50% and 90% of repolarization was decreased, while action potential duration measured at 10% of repolarization was increased by dridocainide. In addition, the plateau of the action potential was depressed by the drug. These changes in action potential configuration were not observed in guinea pig or human papillary muscles. The offset kinetics of the dridocainide-induced V max block were different in Purkinje fibres and in ventricular muscle: the slow time constant of recovery of V max was estimated to be 2.5 s in dog Purkinje fibre and 5–6 s in human and guinea-pig papillary muscle. In guinea-pig papillary muscle, the rate of onset of the V max block was 0.15 and 0.2 per action potential in the presence of 0.6 and 2 μmol/l dridocainide, respectively. Dridocainide also decreased the force of contraction in this preparation. On the basis of the present results, dridocainide appears to posess mixed class LC and LA properties, with LC predominance in human and guinea-pig ventricular muscle. Present results also indicate that results of conventional classification of class I drugs may depend on the parameters chosen, as well as on the preparation selected.
    Type of Medium: Electronic Resource
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