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  • 1
    Electronic Resource
    Electronic Resource
    Antibiotics from basidiomycetes (1981)
    Springer
    Archives of microbiology 130 (1981), S. 223-227 
    Details
    ISSN: 1432-072X
    Keywords: Antibiotics ; Basidiomycetes ; Pleurotellus hypnophilus ; Galerina cephalotricha ; Hypnophilin ; Pleurotellol ; Pleurotellic acid ; Complicatic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Three new antibiotically active metabolites were isolated from cultures of the fungus Pleurotellus hypnophilus. The structures which are closely related to the coriolins were elucidated by spectroscopic methods. Hypnophilin (1) has a hirsutane sceleton whereas pleurotellol (2) and pleurotellic acid (3) are sesquiterpenoids with novel hirsutane skeletons. The common structural feature of all three metabolites is an α-methylene ketone moiety. The antibiotics inhibited the growth of several bacteria as well as of some fungi. In cells of the ascitic form of Ehrlich carcinoma RNA and DNA syntheses were more affected than protein synthesis. The mode of action was compared with the antimicrobial and cytotoxic effects of complicatic acid (4) and other α-methylene ketones and lactones from higher plants. All the compounds tested reacted rapidly with cysteine to form adducts which were almost devoid of biological activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00459523
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New Triquinane-Type Sesquiterpenoids from Macrocystidia cucumis (Basidiomycetes) (1998)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1998 (1998), S. 73-79 
    Details
    ISSN: 1434-193X
    Keywords: Macrocystidia cucumis ; Cucumins ; Hirsutanes ; Sesquiterpenoids ; Antibiotics ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Arthrosporone (1) and eight new triquinane-type sesquiterpenoids have been isolated from mycelial cultures of the agaric Macrocystidia cucumis. The cucumins A-D (2, 4-6) are highly unsaturated hirsutane derivatives, whereas the cucumins E-G (7-9) represent a new type of linear triquinanes. Cucumin H (10) is a new member of the ceratopicane group. The absolute configuration of cucumin F (8) was assigned by 1H-NMR analysis of the corresponding Mosher esters. Two further metabolites were identified as cyclo(phenylalanylprolyl) (12) and cyclo(leucylprolyl) (13). Cucumin A (2) exhibits antibacterial and cytotoxic activities.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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