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Digitale Medien

High-dose BEAM chemotherapy with autologous peripheral blood progenitor-cell transplantation for unselected patients with primary refractory or relapsed Hodgkin's disease (2000)

Argiris, A. ; Seropian, S. ; Cooper, D. L.

Springer

Annals of oncology 11 (2000), S. 665-672

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ISSN: 1569-8041

Schlagwort(e): autologous peripheral blood progenitor-cell transplantation ; CD34+ cells ; high-dose chemotherapy ; Hodgkin's disease

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Background:The use of autologous peripheral blood progenitorcells (PBPC) expedites hematologic recovery and reduces the costs oftransplantation in comparison with autologous bone marrow; however, itsefficacy in patients with Hodgkin's disease has been questioned. We evaluatedthe results of autologous PBPC transplantation in a population of unselectedand uniformly treated patients with primary refractory or relapsed Hodgkin'sdisease. Patients and methods:Forty consecutive adult patients withprimary refractory (n = 7) or relapsed (n = 33) Hodgkin'sdisease received high-dose BEAM (BCNU, etoposide, ara-C, and melphalan)followed by autologous PBPC infusion. Twenty-four patients (60%)received high-dose BEAM as outpatients. Consolidative radiation therapy wasadministered to 14 patients (35%). Results:Thirty-seven patients (92%) achieved a posttransplant complete response. The 3-year progression-free survival (PFS) was69%, and the 3-year overall survival (OS) was 77%, with a medianfollow-up of surviving patients of 28 months. Severe non-hematologictoxicities included gastrointestinal side effects (diarrhea 17%,mucositis 25%), and interstitial pneumonitis (15%). One patientdied of acute transplant-related complications (mortality rate 2.5%).Strong predictors of poor PFS were chemoresistant versuschemosensitive/untested disease (actuarial PFS 89% versus22%, P = 0.0000) and stage IIB–IV versusI–IIA at relapse/progression (86% versus46%, P = 0.005). All five patients with elevated lactatedehydrogenase at the time of transplantation died of their disease. There wasa trend toward worse PFS for patients receiving a higher number of CD34+ cells(≥11 × 106 per kg). Conclusions:High-dose BEAM chemotherapy with autologous PBPCtransplantation is associated with low mortality and results in satisfactoryPFS for patients with primary refractory or relapsed Hodgkin's disease. Thesubset of patients with progressive disease at the time of transplantationperforms poorly and may benefit from alternative strategies.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1008396525292

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Digitale Medien

Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodies (1993)

Koren, E. ; Neethling, F. A. ; Richards, S. ; [weitere]

Springer

Transplant international 6 (1993), S. 351-353

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ISSN: 1432-2277

Schlagwort(e): Antibodies, human, preformed ; Pig cells, anti-pig immunoglobulins ; Hyperacture rejection, pig

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Preformed human anti-pig antibodies isolated from perfused pig hearts were used to analyze the binding of various immunoglobulin classes to cultured pig kidney cells. All anti-pig immunoglobulins (i.e., IgG, IgA, and IgM) were localized on the cell surface by the use of an indirect immunofluorescence technique. Anti-pig immunoglobulins also competed for the pig cell surface epitopes with Griffonia simplicifolia lectin (GS-I-B4), which is specific for α-galactosyl residues. This study provides further evidence that preformed human antibodies recognizing α-glactosyl-containing epitopes (anti-gal antibodies) could be an important factor in hyperacute rejection of pig organs.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00335975

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Digitale Medien

Comparison of linear distributed-parameter filters to lumped approximants (1986)

Cooper, D. J. ; Ramirez, W. F. ; Clough, D. E.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 32 (1986), S. 186-194

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ISSN: 0001-1541

Schlagwort(e): Chemistry ; Chemical Engineering

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Optimal distributed-parameter filters are commonly implemented using approximating lumped Kalman filtering theory. The effect of such an approximation is investigated. A theoretical development shows that there is a loss in the spatial noise correlation for the lumped approximants. Two numerical examples of engineering significance illustrate that one result of this loss is slower filter convergence for the lumped approximants relative to the full distributed-parameter filters.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/aic.690320203

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Digitale Medien

Optimal, real-time monitoring of particle size distribution in a fluidized bed (1986)

Cooper, D. J. ; Clough, D. E.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 32 (1986), S. 389-396

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ISSN: 0001-1541

Schlagwort(e): Chemistry ; Chemical Engineering

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: A novel method for tracking particle size distribution dynamics in a fluidized bed yields on-line, real-time measurements of particle size distribution that are representative of actual conditions. These measurements are somewhat corrupted with noise (random error), however, and are available to the computer only at discrete time intervals. An optimal filtering algorithm combines the measurements with predictions from an idealized dynamic model to yield particle size distribution estimates that are not only on-line and real-time, but also virtually continuous and well-behaved.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/aic.690320305

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Digitale Medien

Real-time estimation of dynamic particle-size distributions in a fluidized bed: Theoretical foundation (1985)

Cooper, D. J. ; Clough, D. E.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 31 (1985), S. 1202-1212

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ISSN: 0001-1541

Schlagwort(e): Chemistry ; Chemical Engineering

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Significant noise (random error) is common in an on-line signal when measuring the particle size distribution in a fluidized bed. The application of optimal estimation theory to obtain a filtering algorithm that can rectify such measurements is detailed. Off-line simulation studies demonstrate that the filtering algorithm yields a measure of particle size distribution that is well-behaved, accurate, and able to track in real time as conditions change in the bed.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/aic.690310718

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