ISSN:
1432-2072
Keywords:
Mianserin hydrochloride
;
Amitriptyline
;
Tricyclic antidepressive
;
Tetracyclic antidepressive
;
Primary depressive illness
;
Adrenergic interactions
;
Tyramine-dose/pressor-response test
;
Tyramine sensitivity
;
Anticholinergic effect
;
Pupil diameter
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The clinical pharmacology of mianserin hydrochloride was studied in patients suffering from a primary depressive illness after steady-state plasma concentration of the drug had been achieved. The results were compared with those found with amitriptyline in both open and double-blind studies. The two drugs are equally effective in their antidepressive effect. Mianserin hydrochloride appears to be free of anticholinergic effects as assessed by the measurement of salivary volume, pupil diameter and the interactions with guanethidine and thymoxamine on the pupil. No peripheral adrenergic interaction as studied by the tyramine dose-pressor-response test were observed in patients treated with mianserin hydrochloride (20 mg three times daily).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427291
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