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  • 1
    Digitale Medien
    Digitale Medien
    Direct influence of antidepressants on GTP binding protein of adenylate cyclase in cell membranes of the cerebral cortex of rats (1988)
    Springer
    Journal of neural transmission 71 (1988), S. 165-175 
    Details
    ISSN: 1435-1463
    Schlagwort(e): Antidepressant ; adenylate cyclase ; GTP binding protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recently, it has been suggested that antidepressant drugs exert their pharmacological action through functional changes in the adrenergic-receptor coupled adenylate cyclase system. In the present research, we examined the direct effects of antidepressants on adenylate cyclase (A-cyclase) activity by in vitro incubation of cell membranes from the cerebral cortex of rats with these drugs. All antidepressants examined, such as imipramine, clomipramine, amitriptyline, desipramine, mianserin and zimelidine inhibited A-cyclase in a dose dependent manner. Antidepressants did not exert any influence on Mn2+-induced elevation of A-cyclase, but significantly suppressed F−-stimulated A-cyclase activity. GTP-induced elevation of A-cyclase was completely inhibited by prior incubation with antidepressants. Our conclusion, therefore, is that antidepressants may reduce A-cyclase activity not by inhibiting the function of the catalytic unit of A-cyclase, but by supressing the N-protein function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01245710
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Plasma 1,25-dihydroxyvitamin D concentrations in cords, newborns, infants, and children (1980)
    Springer
    Calcified tissue international 30 (1980), S. 1-3 
    Details
    ISSN: 1432-0827
    Schlagwort(e): 1,25-(OH)2-D ; Children ; Newborns
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Plasma 1,25-dihydroxyvitamin D [1,25-(OH)2-D] was measured in cord serum, newborns, infants, and children. The mean for the values obtained from the six cords was significantly higher than the mean for the older children (6–15 years). The mean for the six newborns (0–1 week) was significantly higher than that for the older children. The mean for the nine infants (1 week-6 months) and the 14 younger children (6 months-6 years) was significantly higher than that for older children. The present study suggests that the perinatal period is associated with a marked increase in 1,25-(OH)2-D.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02408599
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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