ISSN:
1432-1238
Keywords:
Key words Central venous catheter
;
Bacterial colonization
;
Antimicrobial coating
;
Teicoplanin
;
Catheter-related infection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Objective: Antibiotic-coated intravascular catheters may be an effective means of decreasing bacterial colonization and subsequent catheter-related infection. The present study was designed to investigate the retention of the antibiotic teicoplanin on a hydromer-coated intravenous catheter and the effect of this antibiotic coating on catheter bacterial colonization. Design: A prospective, randomized pilot study. Setting: Operating rooms (ORs) and an intensive care unit (ICU) at a university hospital. Patients: A consecutive group of 20 male patients undergoing major abdominal surgery. Interventions: Control (C, n=10) or teicoplanin-coated (T; n=10) single-lumen central venous catheters were inserted before surgery in the OR. Catheters were withdrawn at the discretion of the physicians in the ICU after various periods. Measurements: The teicoplanin content of the catheter material was assessed using a bioassay with Bacillus subtilis after complete elution of the antibiotic from the catheter. Bacterial colonization was measured using a quanitative culture technique after the catheter lumen had been flushed and the catheter segments sonicated. Main results: Nearly three-quarters of the initial teicoplanin coating (374±103 μg; mean±SD) were released during the first day of catheterization, and after 36 h of intravenous catheterization, no antibiotic was retained on the catheter. No significant difference could be found either in the incidence of bacterial colonization between test (n=3) and control (n=4) catheters or in the number of colony-forming units (CFU) on the catheter segments (T, 263±104 CFU/cm; C, 372±294 CFU/cm; mean±SEM). Conclusion: The retention of teicoplanin antibiotic coating on hydromer catheters is only short term if catheters are inserted intravenously. This may limit clinical antibacterial efficacy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01699229
Permalink
