ISSN:
1432-0533
Keywords:
Astrocyte
;
Macrophage
;
Lymphocyte
;
Major histocompatibility complex antigens
;
Cellular immunity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Frozen samples from 23 low grade (grade I and II) astrocytomas were studied by means of a panel of monoclonal antibodies to macrophages, lymphocytes (and their subsets) and HLA-DR antigens. Macrophages were present in low to moderate numbers in 38%–86% of cases, the variance in figures depending on the antibody used. T lymphocytes, the majority of CD8 phenotype, were detected in low numbers in 78% of tumours. B lymphocytes were scanty in 22% (5/22) and totally absent in the remaining cases. HLA-DR antigen was expressed by tumour cells in 35% (6/17) of cases. These findings indicate that in some low grade astrocytomas there is a mononuclear cell infiltrate with macrophages and secondarily CD8+lymphocytes playing the major role. The significance of these findings remains speculative at present.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687776
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