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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 82 (1978), S. 157-164 
    ISSN: 1437-1596
    Keywords: Documentation of Autopsies ; Violent Death Documentation ; Autopsiebefunde, Dokumentation ; Dokumentation, Autopsiebefunde ; Gewaltsamer Tod, Dokumentation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Es wird über die Erstellung einer Dokumentation des gesamten Obduktionsgutes des Institutes für Rechtsmedizin der Universität München (über 30.000 Fälle) aus den Jahren 1911-1974 berichtet. Die Auswertung der hierin enthaltenen „Gewaltsamen Todesursachen” ergab u.a. folgende Resultate: An den Verkehrsunfällen ist der historische Trend der Motorisierung abzulesen. Bei Tötungen mit Waffen zeigt sich seit 1965 eine deutliche Zunahme. Vergiftungen, nach dem 2. Weltkrieg stark angestiegen, werden heute mit anderen Mitteln durch geführt als vor 1955. Der prozentuale Anteil der Todesursachen bei äußerer Er stickung ist über die Zeit etwa gleich geblieben. Tödliche Abtreibungen sind nach 1946 deutlich zurückgegangen. Obduktionen wegen tödlicher Geburtsverletzun gen, vor und im 2. Weltkrieg an Häufigkeit z. B. mit tödlichen Intoxikationen zu vergleichen, stellen heute eine Seltenheit dar. Der Vorteil der raschen Zugriffs möglichkeit zu Fällen mit seltenen Todesursachen wird diskutiert.
    Notes: Summary We receiwed cases of violent death from more than 30,000 autopsies made at the Institute of Legal Medicine of the Munich University in the years 1911–1974 with the following results: The historical trend in motorisation is among others the following results: The historical trend in motorisation can be reflected by the number of traffic accidents. Killing by use of arms have increased significantly since 1965. Since the end of World War 11 there have been many more cases of poisoning, which today occur with different substances as compared with those used up to 1955. The percentage of death caused by suffocation due to external causes remained almost the same during the analysed period. Fatal abortions have declined distinctly since 1946. Up to the end of World War II autopsies resulting from birth injuries are comparable in frequency to, e.g., fatal intoxications; nowadays the are a rarity. The advantage of ready access to cases of rare death causes is discussed.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Biliary mucus ; Nonsteroidal anti-inflammatory drugs ; Cholesterol nucleation time
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients. The mechanisms by which NSAIDs exert these effect are unclear. In a prospective, controlled clinical trial we examined the effects of oral indomethacin on the composition of human gall-bladder bile. The study included 28 patients with symptomatic cholesterol or mixed gallstones. Of these, 8 were treated with 3 × 25 mg indomethacin daily for 7 days prior to elective cholecystectomy while 20 received no treatment and served as controls. Bile and tissue samples from the gallbladder were obtained during cholecystectomy. Indomethacin tissue levels in the gallbladder mucosa, as assessed by HPLC, were 1.05±0.4 ng/mg wet weight, a concentration known to inhibit effectively cyclooxygenase activity. Nevertheless, no differences between the treated and untreated groups were found in the concentrations of biliary mucus glycoprotein (0.94±0.27 versus 0.93±0.32 mg/ml) or total protein (5.8±0.9 versus 6.4±1.3 mg/ml), cholesterol saturation (1.3±0.2 versus 1.5±0.2), or nucleation time (2.0±3.0 versus 1.5±2.0 days). However, biliary viscosity, measured using a low-shear rotation viscosimeter, was significantly lower in patients receiving indomethacin treatment (2.9±0.6 versus 5.6±1.2 mPa.s; P 〈 0.02). In conclusion, in man oral indomethacin decreases bile viscosity without alteration of bile lithogenicity or biliary mucus glycoprotein content. Since mucus glycoproteins are major determinants of bile viscosity, an alteration in mucin macromolecular composition may conceivably cause the indomethacin-induced decrease in biliary viscosity and explain the beneficial effects of nonsteroidal anti-inflammatory drugs in gallstone disease.
    Type of Medium: Electronic Resource
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