ISSN:
1432-1106
Keywords:
Binding
;
Autoradiography
;
3H-serotonin
;
3H-ketanserin
;
Tissue culture
;
Brain stem
;
Spinal cord
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary By means of lightmicroscopic autoradiography we have studied the cellular localization of binding sites for 3H-serotonin and 3H-ketanserin in organotypic cultures of rat brain stem and spinal cord. In both types of cultures, a relatively great number of neurones revealed binding sites for 3H-serotonin which predominantly labels S1-receptors. 3H-ketanserin, an S2-antagonist was also bound to many neurones although to a lesser extent than 3H-serotonin. Binding sites for both radio-ligands were also observed on astrocytes. These findings together with electrophysiological investigations indicate that astrocytes possess serotonin receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00236324
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