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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 38 (1980), S. 241-243 
    ISSN: 1432-1106
    Keywords: Binding ; 3H-GABA ; 3H-muscimol ; Cerebellum ; Tissue culture ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autoradiographic studies were conducted on the binding of3H-GABA and3H-muscimol in cultures of rat cerebellum. Binding sites for both substances were observed on many cerebellar neurones, such as Purkinje cells and interneurones, but not on glial cells. Binding of3H-GABA and3H-muscimol was inhibited by unlabelled GABA and by the GABA antagonist bicuculline.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1106
    Keywords: Binding ; Autoradiography ; 3H-serotonin ; 3H-ketanserin ; Tissue culture ; Brain stem ; Spinal cord
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary By means of lightmicroscopic autoradiography we have studied the cellular localization of binding sites for 3H-serotonin and 3H-ketanserin in organotypic cultures of rat brain stem and spinal cord. In both types of cultures, a relatively great number of neurones revealed binding sites for 3H-serotonin which predominantly labels S1-receptors. 3H-ketanserin, an S2-antagonist was also bound to many neurones although to a lesser extent than 3H-serotonin. Binding sites for both radio-ligands were also observed on astrocytes. These findings together with electrophysiological investigations indicate that astrocytes possess serotonin receptors.
    Type of Medium: Electronic Resource
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