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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of insulin secretion: the role of second messengers (1994)
    Springer
    Diabetologia 37 (1994), S. S30 
    Details
    ISSN: 1432-0428
    Keywords: Islets of Langerhans ; insulin secretion ; protein kinase A ; cyclic AMP ; calcium-calmodulin ; protein kinase C ; arachidonic acid ; nitric oxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This review summarises briefly studies performed in the last 5–6 years concerning the role of second messengers in the regulation of insulin secretion, using intact and electrically permeabilized rat islets of Langerhans. It is concluded that cyclic AMP (through protein kinase A), calcium (through calcium-calmodulin dependent protein kinases) and diacylglycerol (through protein kinase C) may be important second messengers in modulating the effects of specific secretagogues on insulin release. However, recent studies strongly suggest that neither protein kinase A nor protein kinase C are directly involved in the regulation of insulin secretion by glucose. The possible involvement of other second messengers, nitric oxide and arachidonic acid, in the regulation of secretion is also briefly reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400823
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Insulin secretion: The effector system (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1098-1105 
    Details
    ISSN: 1420-9071
    Keywords: Insulin secretion ; regulation of ; microtubule-granule interactions ; B-cell cytoskeleton ; exocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusions Studies of the role of the microtubule-microfilamentous system in insulin secretion have been widened by continuing experimentation and analysis to provide a comprehensive working hypothesis which embraces ideas of the way in which the polymerization of microtubules and microfilaments may be regulated and how these cytoskeletal components may act together to enhance the process of granule movement. It is also possible to speculate about, but not yet to demonstrate, the way in which the activities of this effector system could be regulated by calcium and by cyclic AMP, which are essentially involved in the regulation of rates of secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971457
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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