ISSN:
1432-1076
Keywords:
BCG infection
;
Severe combined immunodeficiency
;
Omenn syndrome
;
Bone marrow transplantation
;
Hypertrophic non-obstructive cardiomyopathy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We report successful bone marrow transplantation (BMT) in two patients with severe combined immunodeficiency (SCID), who had developed BCG infection following neonatal vaccination. Patient 1 had Omenn Syndrome, associated with hypertrophic nonobstructive cardiomyopathy. Patient 2 had SCID due to adenosine deaminase deficiency. This communication demonstrates that with appropriate anti-mycobacterial cover, immunological reconstitution together with full recovery from BCG infection can be achieved by BMT. As demonstrated by persistant negative Mantoux tests, specific cell-mediated immunity to BCG was not acquired following BMT. We suggest that these children may continue to be at risk from mycobacterial infection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01958426
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