ISSN:
1573-2568
Keywords:
BLEEDING
;
NSAIDS
;
OUTCOME
;
MORTALITY
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Although nonsteroidal antiinflammatory drug(NSAID) use is strongly associated with both uppergastrointestinal bleeding (UGIB) and lowergastrointestinal bleeding (LGIB), few data existregarding the outcome of the bleeding episode for those consumingthese drugs. Consecutive patients with UGIB or LGIBevaluated during the period August 1, 1990 throughSeptember 30, 1994 at a large inner city hospital were prospectively identified. Both prescription andover-the-counter NSAID use was specifically evaluated.Endoscopy was performed in most patients for diagnosis.Outcome measures included transfusion requirement, hospital stay, need for endoscopic therapy orsurgery, and death. Over the 50-month study period, 785patients admitted with UGIB and 161 with LGIB werestudied. NSAID use was documented in 59% of patients with UGIB and 51% with LGIB. In UGIB, NSAIDusers were more likely to be female and older. NSAIDusers had a significantly shorter median hospital stay(4 vs 5 days), less rebleeding (11% vs 18%; P = 0.004) and in-hospital mortality (5% vs 13%; P =0.001) as compared to nonusers. These differencesremained significant when controlling for age, race, andgender. Similar trends in outcome were seen whenevaluating ulcer- and non-ulcer-related bleeding. NSAIDusers with LGIB were more likely to be female, althoughrebleeding (19% vs 21%), hospital stay, and in-hospitalmortality (5% vs 2%) were not significantly different between users and nonusers. UGIB in NSAID usersappears to have a better prognosis as compared tononusers. In contrast, NSAID use does not appear to beassociated with outcome in patients with LGIB.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018880818217
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