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  • 1
    ISSN: 1437-7772
    Keywords: Key words Ovarian cancer ; High-dose chemotherapy ; Autologous bone marrow transplantation ; Prognostic factor ; Long-term follow-up
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The efficacy of high-dose chemotherapy (HDC) with autologous bone marrow transplantation (ABMT) was evaluated in patients with advanced or recurrent/refractory (r/r) epithelial ovarian cancer in terms of long-term results and prognostic analysis. Methods. Between 1984 and 1991, 47 patients were prescribed two courses of HDC, consisting of cyclophosphamide (1600–2400 mg/m2), adriamycin (80–100 mg/m2), and cisplatin (100–150 mg/m2) after maximal cytoreductive surgery. Prior to HDC, platinum-based chemotherapy was administered for optimal cytoreduction. Results. The 5- and 8-year overall survival (OS) rates (%) of the 47 patients were 44.7% and 40.4%, and the 5- and 8-year disease-free survival (DFS) rates (%) were 29.8% and 27.7%, respectively. The 5- and 8-year OS rates (%) by stage were: stage III, 60.0% and 52.0%; stage IV, 33.3% and 33.3%; and r/r, 20.0% and 20.0%. The 5- and 8-year DFS rates (%) by stage were: stage III, 40.0% and 36.0%; stage IV, 25.0% and 25.0%; and r/r, 10.0% and 10.0%, respectively. Significantly better long-term survival (P 〈 0.01) was obtained in the group with no residual disease or residual disease 〈0.5 cm than in the groups with residual disease of 0.5–2 cm and 〉2 cm. In the 32 stage III/IV patients, the group given two courses of 150 mg/m2 cisplatin (n = 18) showed significantly better long-term survival (P 〈 0.05) than another group given two courses of 100 or 120 mg/m2 cisplatin (n = 14). Conclusions. Administration of two courses of HDC con-taining 2400 mg/m2 cyclophosphamide, 100 mg/m2 adriamycin, and 150 mg/m2 cisplatin per course followed by ABMT appears to be a promising procedure for achieving long-term survival in patients with chemosensitive advanced or r/r epithelial ovarian cancers with no or minimal residual disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 14 (1992), S. 251-257 
    ISSN: 1279-8517
    Keywords: Length of the large intestine ; Diameter of the large intestine ; Size of the large intestine ; Barium enema examination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La longueur, le diamètre et la surface développée de chacun des six segments du colon ont été mesurés sur une série de 920 lavements barytés pratiqués chez des patients Japonais. Le colon transverse est le segment le plus long et le plus étendu en surface, suivi par le colon sigmoïde. Le diamètre du colon ascendant est le plus important, tandis que ceux du colon descendant et du sigmoïde sont les plus étroits. Des différences de taille du colon en fonction du sexe ont été observées. La longueur et la surface de la totalité du colon étaient toutes deux moins importantes chez les hommes que chez les femmes. Les longueurs du caecum, du colon ascendant, du colon transverse et du rectum, sont également moins importantes chez les hommes que chez les femmes. Les diamètres du colon descendant, du colon sigmoïde et du rectum sont plus importants chez les hommes que chez les femmes. La surface développée du colon ascendant et du colon transverse est moins étendue chez les hommes que chez les femmes, tandis que le total des surfaces du colon descendant, du colon sigmoïde et du rectum, est plus important chez les hommes que chez les femmes. La longueur totale du colon tend à augmenter avec l'âge. La longueur et la surface de l'ensemble du colon a également tendance à augmenter chez les femmes avec importance du morphotype.
    Notes: Summary Length, diameter and surface area of each of 6 segments of the large intestine were determined and calculated in 920 Japanese patients who underwent barium enema. Of the length and surface area measurements obtained, those of the transverse colon were the largest, followed by those of the sigmoid colon. The diameter of the ascending colon was the largest, while those of the descending colon and sigmoid colon were the smallest. There were various sex differences in size of the large intestine. Length and surface area of the entire large intestine in males were shorter and smaller respectively than those in females. Lengths of the cecum, ascending colon, transverse colon and rectum in males were shorter than those in females. Diameters of the descending colon, sigmoid colon and rectum in males were larger than those in females. Total surface areas of the ascending colon and transverse colon in males were smaller than those in females, while total surface areas of the descending colon, sigmoid colon and rectum in males were larger than those in females. Length of the entire large intestine tended to be increased with age. Length and surface area of the entire large intestine tended to be increased with an increase in physical dimensions in females.
    Type of Medium: Electronic Resource
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