ISSN:
1040-0397
Keywords:
Aminohalogenbenzophenones
;
Benzodiazepinooxazoles
;
Pharmaceutical preparations
;
Pulse voltammetry
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An electroanalytical study of three aminohalogenbenzophenones: 2-amino-5-chlorobenzophenone (MCB), 2-amino-2′,5-dichlorobenzo-phenone (DCB), and 2-amino-5-bromo-2′-fluorobenzophenone (BrFB); metabolites of the psychotropic drugs benzodiazepinooxazoles and benzodiazepines, has been carried out at a glassy carbon electrode using different voltammetric techniques. The compounds studied are electrooxidizable in a hydroalcoholic medium (MeOH:H2O, 10 : 90), 0.5 M KC1, and a pH range of 1-13. The oxidation processes are irreversible and predominantly diffusion controlled. On the basis of the oxidation process, voltammetric methods have been developed that allow the determination of aminohalogenbenzophenones from 0.2 to 15ppm for MCB and BrFB, and 0.2 to 14ppm for DCB; with a reproducibility in terms of relative standard deviation (RSD) lower than 5.2% for 10 determinations of 10 ppm solutions of MCB, DCB, and BrFB. Detection limits of 200ppb (μg/L) for MCB and DCB, and 100ppb for BrFB were obtained. The voltammetric method developed for DCB has been applied to the indirect determination of Cloxazolam in tablets.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elan.1140070216
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