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Mescaline-induced changes of brain-cortex ribosomes mescaline demethylase activity of brain-cortex soluble supernatant (1977)

Datta, R. K. ; Ghosh, J. J.

Springer

Naunyn-Schmiedeberg's archives of pharmacology 296 (1977), S. 297-300

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ISSN: 1432-1912

Keywords: Brain-cortex slices ; O-demethylase ; Mescaline ; Soluble supernatant

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Brain-cortex slices demethylate mescaline and p-methoxyacetanilide, a reference O-demethylating substrate, though the rate of demethylation of mescaline is about one third that of the reference substrate. The demethylase activity is localized mostly in the soluble supernatant (105000xg). It is purified 47-fold with respect to the demethylation of mescaline by ammonium sulfate precipitation and DEAE cellulose chromatography. The partially purified demethylase, which is stable for 3–5 days at −5° C in the presence of dithiothreitol and glutathione and is inhibited by p-chloromercuribenzoate, has maximal activity at pH between 7.2 and 8.0. It demethylates mescaline into 3,4-dimethoxy-5-hydroxyphenethylamine and 3,5-dimethoxy-4-hydroxyphenethylamine and some unidentified derivatives.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00498697

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Discrimination of isomeric structures using information theoretic topological indicesOriginal proofs of this paper were lost in the mail. (1984)

Raychaudhury, C. ; Ray, S. K. ; Ghosh, J. J. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Computational Chemistry 5 (1984), S. 581-588

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ISSN: 0192-8651

Keywords: Computational Chemistry and Molecular Modeling ; Biochemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Computer Science

Notes: Three newly defined information theoretic topological indices, namely “degree complexity (Id),” “graph vertex complexity (HV),” and “graph distance complexity (HD)” along with three other information indices have been used to study their discriminating power of 45 trees and 19 monocyclic graphs. It is found that the newly defined indices have satisfactory discriminating power while HD has been found to be the only index to discriminate all the graphs studied.

Additional Material: 4 Ill.