ISSN:
1573-2630
Keywords:
aqueous humor
;
Fuchs heterochromic cyclitis
;
IgG subclass
;
herpetic uveitis
;
toxoplasmic chorioretinitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Changes in local immunity are important whenconsidering the physiopathology of uveitis. The aim ofthis study was to measure IgG and IgG subclassconcentrations in the serum and the AH of patients withthree different types of uveitis and to determine for eachof them the presence of a local production of IgG in theintra-ocular compartment. This investigation was extendedto IgG subclasses.Serum and AH of 46 patients, including 11 with Fuchsheterochromic cyclitis (FHC), 13 with toxoplasmicchorioretinitis, 11 with herpetic uveitis and 11 with senilecataract (taken as controls) were analyzed by ELISA forIgG and IgG subclasses. Three quotients (r1, IgG/albuminin serum; r2, IgG/albumin in AH; and R, r2/r1) werecalculated in order to estimate the local synthesis (LS) ofIgG and each IgG subclass.In AH of patients with herpetic uveitis, a concomitant andsignificant increase of all IgG subclasses as well asalbumin (with no significant increase of r2 or R) wasobserved. This finding was interpreted as an indirectconsequence of major damage to the blood–aqueousbarrier. In patients with FHC, a significant increase of r2and R involving only the IgG1 subclass was observed,indicating the existence of LS of IgG1 in the majority ofthese patients. In the AH of patients with toxoplasmicchorioretinitis, no significant modification of IgG subclassor albumin concentrations was observed when comparedto controls.In conclusion, it would seem interesting to considermeasurement of IgG and IgG subclasses and calculationof the coefficients r1, r2 and R for a better evaluation ofthe local immunological processes observed in differenttypes of uveitis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005909331778
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