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Implantation of programmable infusion pumps for insulin delivery in type I diabetic patients (1989)

Walter, H. ; Günther, A. ; Kronski, D. ; [et al.]

Springer

Journal of molecular medicine 67 (1989), S. 583-587

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ISSN: 1432-1440

Keywords: Insulin infusion pump ; Implantation ; CSII ; Intravenous, intraperitoneal insulin infusion

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Five type I diabetic patients were followed prospectively during treatment with continuous subcutaneous insulin infusion by externally worn pumps and during the first 12 months after implantation of a remote-controlled insulin infusion device (ID1, Siemens AG). Stabilized insulin (Hoe 21 GH, Hoechst AG) was infused intravenously in two and intraperitoneally in three patients. Total observation time was 47.2 patient-months after implantation. Two devices had to be explanted prematurely, one because of a technical failure after 101 days, one due to a skin necrosis over the implant after 236 days. HbA1, frequency of hypoglycemia, total insulin dose, and basal rate infusion did not change after implantation. There was a reduction in the insulin antibodies 6 months after start of intravenous or intraperitoneal insulin delivery. Fasting plasma free insulin levels could be normalized only by intraperitoneal insulin infusion. Although a technical and a surgical problem was observed, our data show the successful implantation and clinical use of programmable dosing devices and stabilized insulin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01721685

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Effects of diffusion limitation on immobilized nitrifying microorganisms at low temperatures (1995)

Wijffels, R. H. ; Hunik, J. H. ; Leenen, E. J. T. M. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 45 (1995), S. 1-9

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ISSN: 0006-3592

Keywords: nitrification ; immobilized cells ; activation energy ; diffusion limitation ; temperature ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Activation energies of suspended and immobilized nitrifying bacteria were determined and compared to determine if diffusion limitation results in decreased sensitivity for temperature. The activation energy for the respiration activity of suspended Nitrosomonas europaea and Nitrobacter agilis was found to be 86.4 and 58.4 kJ mol-1, respectively. The activation energy for oxygen diffusion in the support material, κ-carrageenan, determined from the effect of temperature on the effective diffusion coefficient (D), was 17.2 kJ mol-1. Consequently, the apparent actvation energy of diffusion limited cells should be lower. It was indeed shown that due to the effect of diffusion limitation and to temperature effects on the Monod constant Ks, the immobilized-cell activity was less sensitive to temperature. The apparent activation energy for immobilized Ns. europaea was between 28.6 and 94.2 kJ mol-1 and for immobilized Nb. agilis between 1.4 and 72.9 kJ mol-1, depending on the oxygen concentration and temperature. © 1995 John Wiley & Sons, Inc.

Additional Material: 8 Ill.