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  • 1
    Electronic Resource
    Electronic Resource
    Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency in two sibs (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 351-354 
    Details
    ISSN: 1432-1076
    Keywords: 3-Methylcrotonyl-CoA carboxylase ; 3-Hydroxyisovaleric acid ; 3-Methylcrotonylglycine ; Biotin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two Vietnamese siblings with an isolated deficiency of 3-methylcrotonyl coenzyme A carboxylase in leucocytes and culture fibroblasts are described. Both children excreted massive amounts of 3-methylcrotonylglycine and 3-hydroxyisovaleric acid. There was no in vivo or in vitro biochemical response to biotin. Apart from an attack of vomitting leading to subcoma in the elder sib four weeks after arrival in the Netherlands, the children were in good health. There were no signs of delayed mental development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442517
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  • 2
    Electronic Resource
    Electronic Resource
    Holocarboxylase synthetase deficiency: Early diagnosis and management of a new case (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 446-449 
    Details
    ISSN: 1432-1076
    Keywords: Holocarboxylase synthetase deficiency ; Multiple carboxylase deficiency ; Organic aciduria ; Biotin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present a new case of holocarboxylase synthetase (HCS) deficiency, a rare autosomal recessive metabolic disorder, causing the “early-onset” form of multiple carboxylase deficiency. The patient was born at term of healthy consanguineous parents after an uncomplicated pregnancy. On the 2nd day of life she refused oral feeding, became tachydyspnoeic and showed excessive weight loss. Laboratory studies showed metabolic acidosis, marked lactic acidaemia, hyperammonaemia and increased urinary excretion of 3-hydroxyisovaleric acid, 3-methylcrotonyglycine, 3-hydroxypropionic acid and methylcritric acid. Peritoneal dialysis combined with oral supplementation of biotin (10 mg/day) started on the 3rd day of life resulted in rapid clinical recovery and normalisation of biochemical parameters. HCS deficiency was established in lymphocytes and skin fibroblasts. The activities of all biotin-dependent carboxylases were severely decreased in fibroblasts grown in medium with moderate biotin concentration (10−8 mol/l) but normal in a high biotin medium (10−5 mol/l). Mitochondrial carboxylase activities in lymphocytes were 23%–29% of mean normal during therapy with 20 mg of biotin/day, with the higher dose of 40 mg/day they were within (3-methylcrotoryl-CoA carboxylase, pyruvate carboxylase) or slightly below (propionyl-CoA carboxylase) the normal range. At the age of 3 years the patient's physical and psychomotor development are normal. Early biotin supplementation should be considered in newborns with lactic acidosis and organoaciduria until a final diagnosis has been established. Furthermore, the required individual dose of biotin has to be carefully evaluated biochemically for the individual patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955908
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  • 3
    Electronic Resource
    Electronic Resource
    The electrochemical synthesis of neutral Nickel(II) Complexes of Schiff Base Ligands: The crystal structure of bis-{N-[2-(2-pyridyl)ethyl]salicylideneiminato}nickel(II) trihydrate (1989)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 573 (1989), S. 215-222 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Elektrochemische Synthese von neutralen Nickel(II)-Komplexen mit Schiffschen Basen: Kristallstruktur von Bis-{N-[2-(2-pyridyl) äthyl]-salicylideneiminato}nickel(II) TrihydratNickel(II)-Komplexe mit im Pyridin-Ring substituiertem N-2-(2-pyridyl)-äthyl-salicylideneiminat wurden durch Elektrolyse einer nicht wäßrigen Lösung des entsprechenden Liganden hergestellt; als Anode diente ein Ni-Draht. Die Struktur von Bis-{N-[2-(2-pyridyl)äthyl]-salicylideneiminato}nickel(II). Trihydrat wurde röntgenographisch bestimmt. Der Komplex kristallisiert triklin in der Raumgruppe P1 mit den Gitterkonstanten a = 13,055(4) Å, b = 13,097(6)Å, c = 16,189(5) Å, α = 102,92(3)°, β = 99,80(3)°, γ = 90,42(3)° und Z = 4. Eine Least-squares-Verfeinerung führte zu einem R-Wert von 0,047. Das Molekül ist nicht zentrosymmetrisch, da die zwei dreizähnigen Liganden eine meridionale Konfiguration um das oktaedrisch koordinierte Nickel(II) annehmen.
    Notes: Nickel(II) complexes with N-2-(2-pyridyl)ethyl-ring substituted salicylideneiminatos have been synthesized by an electrochemical procedure using a sacrificial anode in non-aqueous solution of the corresponding ligand. The structure of bis{N-[2-(2-pyridyl)]-salicylideneiminato}-nickel (II) trihydrate has been determined by X-ray diffraction. Crystals are triclinic, space group P1, with four formula units in a cell of dimensions a = 13.055(4) Å, b = 13.097(6) Å, c = 16.189(5) Å, and α = 102.92(3)°, β = 99.80(3)°, γ = 90.42(3)°. Full matrix least squares refinement on R converged with a conventional agreement factor of 0.047. The molecule is non-centrosymmetric with two terdentate ligands in a meridional configuration around octahedral nickel(II).
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19895730122
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  • 4
    Electronic Resource
    Electronic Resource
    Direct electrochemical synthesis and crystal structure of the Zinc(II) Carbamato Complex {[N-methyl-N′-[(2-pyrrolyl)-methylene]ethylenediamine][N-methyl-N-[2-[(2-pyrrolato)-methyleneamino]ethyl]carbamato]}zinc(II) (1990)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 586 (1990), S. 203-208 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Direkte elektrochemische Synthese und Kristallstruktur des Zink(II)-carbamato-Komplexes{[N-methyl-N′-[(2-pyrrolyl)methylen]ethylendiamin][N-methyl-N-[2-[(2-pyrrolato)methylenamino]ethyl]carbamato]}zink(II)Die elektrochemische Oxidation von anodischem Zink in Acetonitril-Lösung einer Schiffschen Base, die aus Hpyrrol-2-carbaldehyd und N-methylethyldiamin dargestellt wurde, ergibt[Zn(C8H13N3)(C9H11N3O2)], dessen Kristallstruktur röntgenographisch bestimmt wurde. Die Verbindung kristallisiert im orthorhombischen Kristallsystem, mit der Raumgruppe Pbca und a = 13,757(2), b = 17,748(4), c = 14,808(4) Å, Z = 8. Die Verfeinerung führte bis zu einem R-Wert von 0,049 für 1407 unabhängige, beobachtete Reflexe. Die Kristallstruktur besteht aus monomeren Molekülen, in denen die zentrale ZnN4O-Einheit eine verzerrt trigonal bipyramidale Geometrie aufweist. Die Carbamatogruppe ist einzähnig gebunden.
    Notes: The electrochemical oxidation of anodic zinc in an acetonitrile solution of a Schiff base derived from Hpyrrole-2-carbaldehyde and N-methylethylenediamine gives [Zn(C8H13N3)-(C9H11N3O2)], whose crystal structure has been determined. The compound crystallizes in the orthorhombic space group Pbca (No. 61) with a = 13.757(2), b = 17.748(4), c = 14.808(4) Å and Z = 8. Refinement converged to R = 0.049 for 1407 independent observed reflections. The crystal structure consists of monomeric molecules in which the central ZnN4O unit has distorted trigonal bipyramidal geometry and the carbamato group is monodentate.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19905860126
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  • 5
    Electronic Resource
    Electronic Resource
    Electrochemical synthesis of Nickel(II) Complexes of schiff bases: The crystal structure of 2,2′-bipyridine bis{2-[(phenyl)iminomethyl]pyrrolato}nickel(II) (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 612 (1992), S. 83-88 
    Details
    ISSN: 0044-2313
    Keywords: Electrochemical synthesis ; nickel(II) complexes of Schiff bases ; 2,2′ bipyridine bis 2-(phenyl)-iminomethyl pyrrolato nickel(II) ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Elektrochemische Synthese von Nickel(II)-Komplexen mit Schiffschen Basen: Kristallstruktur von 2,2′-Bipyridin-bis{2-[(phenyl)iminomethyl]pyrrolato}nickel(II)Die elektrochemische Oxidation von anodischem Nickel in einer Acetonitril-Lösung mit einer aus H-pyrrole-2-carbaldehyd abgeleiteten Schiffschen Base, einem substituierten Anilin und einem Stickstoff-Liganden (1,10-Phenanthroline (phen), 2,2′-Bipyridin (bipy) oder Pyridin (py)) liefert die gemischten Komplexe NiL2 · phen, NiL2 · bipy bzw. NiL2 · (py)2. Die Kristallstruktur von 2,2′-Bipyridin bis{2-[(phenyl)iminomethyl]-pyrrolato}nickel(II) wurde röntgenographisch bestimmt. Der. Komplex kristallisiert triklin in der Raumgruppe P1, mit den Gitterkonstanten a = 12,316(1), b = 13,169(4), c = 17,251(3) Å, α = 82,67(3)°, β = 83,66(1)°, γ = 87,34(2)°, Z = 4; besteht aus monomeren Molekülen mit der zentralen NiN6-Einheit mit verzerrt oktaedrischer Geometrie.
    Notes: The electrochemical oxidation of anodic nickel in acetonitrile solution containing both (a) a Schiff base HL derived from H-pyrrole-2-carbaldehyde and a substituted aniline, and (b) a nitrogen ligand (1, 10-phenanthroline (phen), 2,2′-bipyridine (bipy) or pyridine (py)) yielded the mixed complexes NiL2 · phen, NiL2 · bipy and NiL2 · (py)2. The crystal structure of 2,2′-bipyridine bis{2-[(phenyl)iminomethyl]pyrrolato}nickel(II) was determined by X ray diffraction. Crystals are triclinic space group P1, with four molecules in the unit cell of dimensions a = 12.316(1), b = 13.169(4), c = 17.251(3) Å, α = 82.67(3)°, β = 83.66(1)° and γ = 87.34(2)°, and consist of monomeric molecules in which the central NiN6 unit has a distorted octahedral geometry.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926120114
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  • 6
    Electronic Resource
    Electronic Resource
    Electrochemical synthesis of metal complexes of schiff bases: The crystal structure of bis{2-[(4-methylphenyl)iminomethyl]pyrrolato}copper(II) (1992)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 615 (1992), S. 155-160 
    Details
    ISSN: 0044-2313
    Keywords: Electrochemical synthesis ; Schiff bases metal complexes ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Elektrochemische Synthese von Metall(II)-Komplexen mit Schiffschen Basen: Kristallstruktur von Bis{2-[(4-methylphenyl)iminomethyl]pyrrolato}kupfer(II)Die elektrochemische Oxidation von anodischem Metall (Nickel, Kupfer, Zink, Cadmium) in einer Acetonitril-Lösung mit einer aus H-pyrrol-2-carbaldehyd abgeleiteten Schiffschen Base eines substitutierten Anilins (HL) liefert die gemischten Komplexe ML2. Die Kristallstruktur von Bis{2-[(4-methylphenyl)iminomethyl]pyrrolato}kupfer(II) wurde röntgenographisch bestimmt. Der Komplex kristallisiert monoklin in der Raumgruppe P21/n, a = 9,356(2), b = 16,697(2), c = 14,145(2) A, β = 108,47(2)°, Z = 4, und er besteht aus monomeren Molekülen, von denen die zentrale CuN4-Einheit eine verzerrt-tetraedrische Geometrie besitzt mit einem Diederwinkel der Flächen von 25,8(3)°. Die IR, 1H-NMR und UV-VIS Spektren werden im Zusammenhang mit der Struktur diskutiert.
    Notes: The electrochemical oxidation of anodic nickel, copper, zinc or cadmium in acetonitrile solutions of Schiff bases (HL) derived from H-pyrrole-2-carbaldehyde and substituted anilines gives compounds of general formula ML2. The crystal structure of bis{2-[(4-methylphenyl)iminomethyl]pyrrolato}copper(II) has been determined by X-ray diffraction. The compound crystallizes in the monoclinic space group P21/n with a = 9.356(2), b = 16.697(2), c = 14.145(2) Å and β = 108.47(2)°. The crystal structure consists of monomeric molecules in which the central CuN4 unit has distorted square-planar geometry with a dihedral angle of 25.8(3)° between the coordination planes. The IR, 1H NMR and UV-visible spectra of the complexes are discussed and related to the structure.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19926150931
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  • 7
    Electronic Resource
    Electronic Resource
    Electrochemical Synthesis of Zinc and Cadmium Complexes of 2-(N-2-pyridyl-formimidoyl)phenol and its methyl derivatives (1988)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 556 (1988), S. 223-226 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Elektrochemische Synthese von Zink- bzw. Cadmium-Komplexen mit 2-(N-2-Pyridyl-formimidoyl)phenol und seinen MethylderivatenDurch elektrochemische Oxydation des Metals als Anode in einer nicht-wäßrigen Lösung des entsprechenden Liganden werden in guter Ausbeute ZnII- bzw. CdII-Komplexe mit den Anionen von Schiffschen Basen hergestellt. Die Basen sind durch Kondensation von Salicylaldehyd mit verschiedenen 2-Aminopyridinen synthetisiert worden. Die Komplexe wurden durch Elementaranalyse, IR und 1H-NMR charakterisiert.
    Notes: Complexes of ZnII and CdII with the anionic forms of the Schiff bases obtained from the condensation between salicyladehyde and several 2-aminopyridines have been synthesized in good yield by electrochemical oxidation of the appropriate sacrificial anode in nonaqueous solution of the corresponding ligand. The resultant compounds have been characterised by elemental analysis, I.R., and 1H-N.M.R.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19885560125
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