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The murine Bis1 seizure gene and the Kcnab2 gene encoding the β2-subunit of the K+ channel are different (2000)

Zerr, P. ; Martin, B. ; Adelman, J. P.

Springer

Neurogenetics 2 (2000), S. 231-234

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ISSN: 1364-6753

Keywords: Key words Kcnab2 ; Bis1 ; K+ channel ; Epilepsy ; Mice

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: ABSTRACT¶We tested the hypothesis that Bis1, a gene involved in seizure regulation in mice which has been localized to the distal part of chromosome 4, was the same as the gene Kcnab2, encoding the β2-subunit for voltage-dependent K+ channels. Two facts suggested this hypothesis: Kcnab2 is located in the 3.1-cM confidence interval containing Bis1 and many studies have shown an involvement of K+ channels in the genesis of seizures. DNA sequence analysis of the coding sequence for Kcnab2 from JE/Le mice revealed no structural alterations which might affect Kcnab2 function. However, several nucleotide changes were observed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/

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