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  • 1
    ISSN: 1040-452X
    Keywords: EGF-like ligands ; Postnatal development ; RT-PCR ; Immunocytochemistry ; Immunoblotting ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Amphiregulin (Ar) and Cripto-1 (Cr-1) are growth promoting peptides that share amino acid sequence homology with epidermal growth factor (EGF). The present study examined Ar and Cr-1 mRNA and protein expression during various stages of C57BL/6 mouse mammary morphogenesis. Reverse transciption-polymerase chain reaction (RT-PCR) was used to detect transcripts for Ar and Cr-1 at all stages of mammary development. Immunocytochemical (ICC) localization demonstrated that in virgin 4-week to mature 12-week-old mouse fourth inguinal mammary gland, Ar and Cr-1 are expressed in the stromal cells, luminal epithelial cells, and myoepithelial cells of the branching ducts. Ar, and to lesser extent Cr-1, were also found in the epithelial cap cells and in the luminal epithelial cells of the advancing terminal end bud (TEB) from virgin 4-week and 6-week-old mice. Western blot analysis demonstrated that both Ar (28 and 26 kDa) and Cr-1 (90, 67, 56, and 21 kDa) proteins are expressed in virgin, 13.5 day midpregnant and in the 14 day lactating mammary gland. In addition, Ar and Cr-1 are associated with developing alveolar structures as determined by ICC. These results imply that together with EGF and transforming growth factor alpha (TGFα), Ar and Cr-1 may play salient roles as modifiers in the morphogenesis and differentiation of the mammary gland. © 1995 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The international journal of advanced manufacturing technology 14 (1998), S. 350-357 
    ISSN: 1433-3015
    Keywords: Blackboard architecture ; Case-based reasoning ; Expert system ; Process design of injection moulding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Process design of injection moulding involves the selection of the injection moulding machine, mould design, production scheduling, cost estimation, and determination of injection moulding parameters. An expert system approach has been used to derive the process solution for injection moulding over the past few years. However, this approach is found to be incapable of determining the injection moulding parameters owing to the fragile nature of the knowledge for setting the moulding parameters. In addition, the existing expert systems for process design lack proper architecture for organising heterogeneous knowledge sources. In this paper, the combination of a blackboard-based expert system and a case-based reasoning approach is introduced to eliminate the deficiency of the existing expert-system approach to process design, from which a computational system for the process design of injection moulding, named CSPD, has been developed. CSPD first derives the process solution including the selection of the injection moulding machine and the mould base, tooling cost, processing cost estimation, and production scheduling based on the blackboard-based expert-system approach. It is then followed by the determination of the injection moulding parameters based on the case-based reasoning approach and the previously derived partial solution.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The international journal of advanced manufacturing technology 14 (1998), S. 239-246 
    ISSN: 1433-3015
    Keywords: Blackboard architecture ; Case-based reasoning ; Expert system ; Process design of injection moulding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The process design of injection moulding involves the selection of the injection moulding machine, mould design, production scheduling, cost estimation, and determination of injection moulding parameters. Expert system approaches have been attempted to derive the process solution for injection moulding in the past few years. However, this approach has been found to be incapable of determining the injection moulding parameters owing to the difficulty in setting the moulding parameters. In addition, the existing expert systems for process design lack the proper architecture for organising a heterogeneous knowledge source. In this paper, the combination of a blackboard-based expert system and case-based reasoning approach is introduced to make up the deficiencies of the existing expert-system approach to the process design, from which a computational system for process design of injection moulding, named CSPD, was developed and described. CSPD first derives the process solution including the selection of injection moulding machine and mould base, tooling cost, and processing cost estimation, and production scheduling based on the blackboard-based expert-system approach. It is then followed by the determination of the injection moulding parameters based on the case-based reasoning approach and the previously derived partial solution.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 162 (1968), S. 157-175 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ultrastructural and histochemical studies have revealed that the mouse colonic mucous membrane receives an extensive autonomic innervation. Nerve fibers enter the mucous membrane through the muscularis mucosae and ramify in the lamina propria where they were often seen in close proximity to smooth muscle cells. Other axons were seen accompanying blood vessels or passing along the basal aspect of the epithelium subjacent to the basement membrane; none were seen either entering the epithelium or within it.Several methods of fixation were employed in order to study their effects on intraaxonal vesicles. It was found that in tissue fixed in either glutaraldehyde in phosphate buffer, or in osmium tetroxide in phosphate buffer, the granular vesicles were better preserved than in tissue fixed in a chrome-osmium tetroxide mixture. The nerve fibers contained mainly agranular vesicles and large granular vesicles (600-1700 Å). Small granular vesicles (300-600 Å) usually associated with adrenergic nerves and specific green fluorescence indicative of catecholamines were only occasionally seen in the mucous membrane. Reserpine depleted the small granular vesicles and also abolished specific fluorescence.Ultrastructural studies showed that the large majority of nerve fibers were acetylcholinesterase positive.These findings indicate that the innervation of the colonic mucous membrane is predominantly cholinergic and that the adrenergic innervation is sparse.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 61 (1937), S. 321-341 
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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