Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats (1998)
    Springer
    Psychopharmacology 135 (1998), S. 361-367 
    Details
    ISSN: 1432-2072
    Keywords: Key words Streptozotocin ; Experimental diabetes mellitus ; Anxiety ; Diazepam ; Brain monoamines ; Tribulin ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The anxiolytic activity of diazepam (DZP) (0.25–1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various anxiety paradigms, including the open-field exploratory behaviour, elevated plus maze and elevated zero maze behaviours and the social interaction tests. In addition, rat brain tribulin activity was also assessed as a biochemical marker of anxiety. The results indicate that diabetic rats showed significantly more anxiogenic activity in comparison to non-diabetic rats on open-field, elevated plus maze, zero maze and social interaction tests. In diabetic rats, brain tribulin activity (MAO-A inhibitory component) was significantly increased. DZP dose dependently produced anxiolytic activity on the various behavioural parameters in non-diabetic rats. DZP (0.5 and 1 mg/kg) partially reversed the anxiogenic behaviour of STZ diabetic rats in elevated plus maze and zero maze tests. However, in open field behaviour and social interaction tests significant anxiolytic activity was observed only at a higher dose of DZP (1 mg/kg). The findings indicate that STZ-induced diabetic rats exhibited augmented anxiety on various experimental paradigms and that the anxiolytic effect of diazepam was less marked in diabetic rats as compared to their euglycaemic counterparts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050523
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Anticonvulsant action of cannabis in the rat: Role of brain monoamines (1978)
    Springer
    Psychopharmacology 59 (1978), S. 293-297 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis indica ; Anticonvulsant action ; Brain monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of brain monoamines in the anticonvulsant action of Cannabis indica resin (CI), against maximal electroshock-induced seizures in albino rats, was investigated by using pharmacologic agents that influence brain monoamine activity. Delta-9-tetrahydrocannabinol content of cannabis resin was estimated to be 17%. The anticonvulsant action of CI (200 mg/kg, i.p.) was significantly inhibited after pretreatment with drugs that reduce brain serotonin activity but not by drugs that reduce brain catecholamine activity. Similarly, the anticonvulsant action of a subanticonvulsant dose (50 mg/kg, i.p.) of CI was potentiated by serotonin precursors but not by catecholamine precursors. Potentiation of the anticonvulsant action of CI by nialamide or by imipramine was inhibited after pretreatment with 5,6-dihydroxytrypt-amine. The results suggest that the anticonvulsant action of CI in the rat is serotonin- and not catecholamine-mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426637
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Structural Studies on Indium and Tin Thiobenzoates (1996)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 129 (1996), S. 1093-1098 
    Details
    ISSN: 0009-2940
    Keywords: Indium tris(thiobenzoate) ; Triethylammonium tetrakis(thiobenzoato)indate ; Tin, butyl-, tris(thiobenzoate) ; Tin, dichloro-, bis(thiobenzoate) ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Indium(III) and tin(IV) thiocarboxylates were prepared and characterized on the basis of their IR, 13C- and 19Sn-NMR data. Indium tris(thiobenzoate) (1) decomposes into a sulfido complex In (S)[S(O)CPh] (2a). The corresponding tris(thioacetate) In[S(O)CMe]3 is thermally too unstable to be isolated. The anionic tetrakis complex [Et3NH]{In[S(O)CPh]4} (3) was characterized by X-ray crystallography which revealed a distorted tetrahedral coordination at the In atom. X-ray diffraction analysis of the complexes BuSn[S(O)CPh]3 (4) and Cl2Sn[S(O)CPh]2 (7) showed distorted tetrahedral and cis-octahedral structures, respectively.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19961290918
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Tetra o-Tolyltin and its Halogen Derivatives (1966)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 344 (1966), S. 102-106 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Tetra-o-tolylzinn wurde in 45proz. Ausbeute mit Hilfe der Wurtz-Reaktion (Petroläther als Lösungsmittel; Hg als Katalysator) dargestellt. Durch Jodierung wurden daraus Tri-o-tolylzinnjodid und Di-o-tolylzinndijodid erhalten; ferner gelang die Darstellung von Tri-o-tolylzinnfluorid.
    Notes: Tetra-o-tolyltin has been prepared in 45% yield for the first time by Wurtz reaction. Optimum yield is obtained using pet-ether (b. p. 65-85) as solvent and small amounts of mercury as catalyst. A mechanism for the role of mercury in the reaction is suggested. Tri-o-tolyltin iodide and hitherto unknown di o-tolyltin di-iodide have been prepared in 65% and 55% yields respectively by controlled iodination of the compound. Tri o-tolyltin fluoride has also been synthesised for the first time in almost quantitative yield.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19663440114
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...