ISSN:
1432-1440
Keywords:
β-Receptorblocking Eye-drops
;
Bronchial Asthma
;
Lung Function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Lung function was studied double blind and randomized in 5 patients with mild asthma bronchiale and 10 normal adults before and 30, 60 and 90 minutes after one drop of 0.5% Timolol, 0.6% Metipranolol or 0.9% NaCl in each eye. In the asthmatics bronchoconstriction was seen after both β-receptor blocking agents, more pronounced after Timolol than after Metripranolol. There was a decrease in the forced expiratory volume in one second (FEV1.0) of 32, respectively 18%. No changes were observed in the normal subjects. In a separate studie no significant changes were seen in the mean values of 10 other asthmatic subjects after 1% Pindolol, 3% Pilocarpin or 0.9% NaCl. However, in two patients FEV1.0 was reduced by 15% and 20% of the control values after applying Pindolol. In summary, not only β-receptorblocking agents without ISA produce a bronchoconstriction in asthmatic subjects, but also β-blocker with ISA in individual cases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01745503
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