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  • 1
    Electronic Resource
    Electronic Resource
    Double blind comparative study of remoxipride and haloperidol in acute schizophrenic patients (1990)
    Springer
    Psychopharmacology 102 (1990), S. 76-84 
    Details
    ISSN: 1432-2072
    Keywords: Atypical neuroleptics ; Remoxipride ; Haloperidol ; Schizophrenia ; Homovanillic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present 6-week double-blind, randomised, multicentre study, the atypical neuroleptic remoxipride was compared to haloperidol in acute schizophrenic patients (DSM-III). Seventy-one patients entered the study, 36 in the remoxipride group and 35 in the haloperidol group. There were ten early withdrawals, four in the remoxipride group and six patients in the haloperidol group. The Present State Examination (PSE) profile revealed a similar reduction in the symptom clusters of psychosis in both treatment groups. Forty-seven per cent of the patients in the remoxipride group and 34% of the patients in the haloperidol group showed clinically relevant improvement (reduction of BPRS total score ≥ 50%). All extrapyramidal symptoms except “glabella tap” occurred significantly less frequently in the remoxipride group as compared to the haloperidol group. Substantially lower incidences of EPS were found by active questioning in the remoxipride group compared to the haloperidol group. In addition, considerably lower incidences were observed in the remoxipride group with respect to drowsiness/somnolence, tiredness/fatigue and concentrating difficulty. At the end of treatment 66% of the patients in the haloperidol group and 22% in the remoxipride group were using anticholinergics. No consistent changes were found in the mean plasma HVA level in either treatment group. In responders (reduction of BPRS total score ≥ 50%) lower baseline HVA levels were observed in both treatment groups. This study indicates that the newly developed neuroleptic remoxipride is an effective antipsychotic compound, which is clinically safe and well tolerated. In particular, few EPS were induced by remoxipride, as compared to haloperidol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245748
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Classification of S-alleles by their activity in S-heterozygotes of brussels sprouts (Brassica oleracea var. Gemmifera (DC.) Schultz) (1982)
    Springer
    Euphytica 31 (1982), S. 603-611 
    Details
    ISSN: 1573-5060
    Keywords: Brassica oleracea var, gemmifera ; Brussels sprouts ; incompatibility ; dominance relationships of S-alleles in pollen and stigma ; S-allele activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Over a period of many years, data on dominance relationships of S-alleles in Brussels sprouts were collected at URL and IVT. The level of activity of S-alleles in heterozygotes was assessed on the basis of the number of pollen tubes that penetrated into the stigma. 209 out of 210 possible combinations between 21 S-alleles were used for this investigation. The S-alleles were grouped separately for activity in pollen and style on the basis of their sensitivity to lose activity in S-heterozygotes. Besides S-allele interaction per se, activity was found to be influenced by environment and genetic background. Results suggest that in stigma, co-dominance is the normal pattern and that deviations are caused by factors other than S-allele interaction as such. In pollen, only three truly recessive alleles were found. Besides several combinations with mutual weakening in pollen, examples of independent weakening were found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00039198
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    Paper (German National Licenses)
    Fulltext
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