ISSN:
1435-232X
Keywords:
Key words Cell motility
;
Binder of Rho GTPase
;
CDC42 TC10
;
Borg4
;
Full-length cDNA
;
Fluorescence in situ hybridization
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The Borg (binder of Rho GTPases) family proteins interact with CDC42 and TC10 in a guanosine triphosphate (GTP)-dependent manner. We have isolated a full-length cDNA of the mouse Borg4 gene, which is a member of this family. Sequence analysis revealed that this gene encoded a putative 349-amino acid protein. By reverse transcription — coupled polymerase chain reaction (RT-PCR) analysis, we observed that Borg4 was expressed ubiquitously in adult tissues. Additionally, we determined the entire cDNA sequence of the putative human Borg4 orthologue. By fluorescence in situ hybridization, mouse Borg4 and the putative human orthologue have been assigned to mouse chromosome 11E and human chromosome 17q24–25, which has been described as syntenic to the mouse region.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s100380070012
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