ISSN:
1432-1335
Keywords:
Autochthonous colonic tumors
;
N-nitrosoacetoxymethyl-methylamine
;
1,2-Dimethylhydrazine
;
5-Fluorouracil
;
Ftorafur
;
CGP 6809
;
CGP 15'720A
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Colonic tumors were induced in male Sprague-Dawley rats by ten applications of 2 mg/kg/week N-nitrosoacetoxymethyl-methylamine (AMMN) or by three applications of 100 mg/kg/month 1,2-dimethylhydrazine (1,2-DMH). Application of AMMN and 1,2-DMH induced selective colonic tumors in 97% and 29–42% of the initial animals, respectively. Colonic-tumor-bearing animals were subjected to monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A. No cures were achieved. The different therapies did not exert any clear influence on the survival time of animals, except for animals pretreated with AMMN and then subjected to ftorafur therapy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00402060
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