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  • CNR  (1)
  • Ja-value  (1)
  • Prostaglandin E1  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Prostaglandin I1 analogues, SM-10902 and SM-10906, affect human keratinocytes and fibroblasts in vitro in a manner similar to PGE1: therapeutic potential for wound healing (1995)
    Springer
    Archives of dermatological research 287 (1995), S. 539-545 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Prostaglandin E1 ; Prostaglandin I1 analogues ; Keratinocytes ; Dermal fibroblasts ; Wound healing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The newly synthesized prostaglandin (PG) I1 analogues, SM-10902 and SM-10906, were compared with PGE1 in terms of their biological effects on cultured normal human keratinocytes (NHKs) and human dermal fibroblasts (HDFs) in order to evaluate their therapeutic potential for cutaneous wound healing. The PGI1 analogues had a direct effect on cell proliferation of HDFs as did PGE1, but inibited cell growth of NHKs in contrast to the stimulatory effect observed with PGE1. In contrast to NHKs stimulated with PGI1 analogues, which exhibited low levels of adenosine 3,5-cyclic monophosphate (cAMP). HDFs stimulated with these analogues responded in a dose-dependent manner with extremely high levels of cAMP. Conditioned media (CM) derived from media in which HDFs had been incubated with both the PGI1 analogues promoted NHK proliferation. HDF production of interleukin (IL)-6 increased in response to the PGI1 analogues. Since IL-6 was shown to promote cell growth of NHKs, enhancement of NHK proliferation by CM was thought to be due to IL-6 derived from HDFs stimulated with the PGI1 analogues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00374073
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    An increase in the influx of calcium ions into cilia induces thigmotaxis inParamecium caudatum (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 831-833 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Paramecium caudatum ; thigmotaxis ; Ja-value ; CNR ; calcium ; ruthenium red ; LaCl3 ; caffeine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract To understand the role of calcium ions in thigmotaxis inParamecium caudatum, the effects of caffeine, ruthenium red and lanthanum (LaCl3) on thigmotaxis were examined. Thigmotaxis in the CNR mutant, which lacks voltage-dependent Ca2+-channels in the ciliary membrane, was also examined. Ruthenium red and LaCl3 suppressed thigmotaxis inP. caudatum, while caffeine enhanced it. The CNR mutant showed hardly any thigmotaxis. It can be thought that an increase in Ca2+ influx and the intraciliary concentration of Ca2+ ions induces thigmotaxis inParamecium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01923998
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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