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Hypothetical interpretation of the calcium paradox in renin secretion (1988)

Taugner, R. ; Nobiling, R. ; Metz, R. ; [et al.]

Springer

Cell & tissue research 252 (1988), S. 687-690

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ISSN: 1432-0878

Keywords: Renin secretion ; Ca-dependence ; Vascular smooth muscle cells ; Afferent arteriole ; Myosin fibers

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Most renin-positive cells of the preglomerular arteriole are intermediate in morphological appearence between smooth muscle cells and epithelioid cells. Intermediate cells contain, in addition to secretory granules, contractile proteins arranged as a sublemmal network. The paradoxical (inhibitory) role of calcium in renin secretion is explained, on the basis of these findings, by an increased tone of the sublemmal network; this might impair the preexocytotic access of renin granules to the cell membrane.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00216658

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