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  • 1
    Digitale Medien
    Digitale Medien
    Interleukin-6 (IL-6) production in carcinoma of the cervix (1996)
    Springer
    Archives of gynecology and obstetrics 258 (1996), S. 25-33 
    Details
    ISSN: 1432-0711
    Schlagwort(e): Interleukin-6 (IL-6) ; Carcinoma of the uterine cervix ; Histologic type ; Carcinogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight well differentiated SCC secreted a large amount (〉 1500 pg/48 h/106 cells) of IL-6 in nude mice. In contrast, poorly differentiated SCC cell lines and all of the 7 adenocarcinoma cell lines secreted a small amount (〈 500 pg/48 h/106 cells of IL-6). The expression of IL-6 mRNA of the cell lines correlated well with their IL-6 secretion potential. However, the expression of IL-6 receptor did not correlate with the IL-6 secretory potential. We also studied the IL-6 secretion of freshly isolated normal squamous epithelium and of dysplastic epithelium. In culture, two normal squamous epithelia secreted a large amount (〉 2000 pg/48 h/106 cells), whereas 8 dysplasia epithelia secreted an extremely small amount (〈 10 pg/48 h/106 cells). About one-third of patients with SCC had a raised serum IL-6 value. IL-6 production may help to differentiate between SCC and adenocarcinoma of the uterine cervix. IL-6 regulation seems to change in the course of SCC carcinogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01370929
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  • 2
    Digitale Medien
    Digitale Medien
    Interleukin-6 (IL-6) production in carcinoma of the cervix (1995)
    Springer
    Archives of gynecology and obstetrics 258 (1995), S. 25-33 
    Details
    ISSN: 1432-0711
    Schlagwort(e): Key words: Interleukin-6 (IL-6) ; Carcinoma of the uterine cervix ; Histologic type ; Carcinogenesis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. Interleukin-6 (IL-6) is a pleiotropic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied the IL-6 secretion in vitro of 15 human cell lines derived from both squamous cell carcinoma (SCC) and adenocarcinoma of the uterine cervix. Four of the eight well differentiated SCC secreted a large amount (〉1500 pg/48 h/106 cells) of IL-6 in nude mice. In contrast, poorly differentiated SCC cell lines and all of the 7 adenocarcinoma cell lines secreted a small amount (〈500 pg/48 h/106 cells of IL-6). The expression of IL-6 mRNA of the cell lines correlated well with their IL-6 secretion potential. However, the expression of IL-6 receptor did not correlate with the IL-6 secretory potential. We also studied the IL-6 secretion of freshly isolated normal squamous epithelium and of dysplastic epithelium. In culture, two normal squamous epithelia secreted a large amount (〉2000 pg/48 h/106 cells), whereas 8 dysplasia epithelia secreted an extremely small amount (〈10 pg/ 48 h/106 cells). About one-third of patients with SCC had a raised serum IL-6 value. IL-6 production may help to differentiate between SCC and adenocarcinoma of the uterine cervix. IL-6 regulation seems to change in the course of SCC carcinogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01370929
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  • 3
    Digitale Medien
    Digitale Medien
    DNA polymorphisms in the ψβ1- and β-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 177-187 
    Details
    ISSN: 1573-4927
    Schlagwort(e): DNA polymorphisms ; ψβ1-globin gene ; δ-globin gene ; β-globin gene ; macaques
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract DNA polymorphisms in the ψβ1-β-globin gene region in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several restriction endonucleases and the human ψβ1, δIVS2, and βIVS2 probes. TheBamHI site 3′ to the β-globin gene was polymorphic inM. fuscata andM. mulatta, while the HincII site and the EcoRI site in the ψβ1-globin gene region was highly polymorphic inM. fuscata andM. mulatta, respectively. These polymorphic sites also seem to be present in other Asian macaques. The present study of the polymorphism at theBamHI site 3′ to the β-globin gene in Asian macaques supports, at the nuclear DNA level, the idea that thefascicularis group includingM. fuscata, M. mulatta, M. cyclopis, andM. fascicularis is different from other Asian macaque groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00554210
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  • 4
    Digitale Medien
    Digitale Medien
    DNA polymorphisms in the ε- and γ-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 189-202 
    Details
    ISSN: 1573-4927
    Schlagwort(e): DNA polymorphism ; ε-globin gene ; γ-globin gene ; macaques
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract DNA polymorphisms in the ε- and γ-globin gene regions in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several different restriction endonucleases and the human ε and γIVS2 probes.M. fuscata andM. mulatta had highly polymorphic sites(BglII andHincII, respectively) in the ε-globin gene region. TheBamHI site in the γ-globin gene region was highly polymorphic inM. mulatta, while theBglII andHindIII sites in the γ-globin gene region were highly polymorphic inM. fuscata andM. mulatta. The presence of the γ-globin gene triplication was frequently observed inM. fuscata. The gain or loss of an additionalBglII site between two γ-globin genes in Asian macaques seems to be very meaningful for discussing genetic relationships among them.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00554211
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  • 5
    Digitale Medien
    Digitale Medien
    DNA polymorphisms in the ψβ1- and β-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 177-187 
    Details
    ISSN: 1573-4927
    Schlagwort(e): DNA polymorphisms ; ψβ1-globin gene ; δ-globin gene ; β-globin gene ; macaques
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract DNA polymorphisms in the ψβ1-β-globin gene region in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several restriction endonucleases and the human ψβ1, δIVS2, and βIVS2 probes. TheBamHI site 3′ to the β-globin gene was polymorphic inM. fuscata andM. mulatta, while the HincII site and the EcoRI site in the ψβ1-globin gene region was highly polymorphic inM. fuscata andM. mulatta, respectively. These polymorphic sites also seem to be present in other Asian macaques. The present study of the polymorphism at theBamHI site 3′ to the β-globin gene in Asian macaques supports, at the nuclear DNA level, the idea that thefascicularis group includingM. fuscata, M. mulatta, M. cyclopis, andM. fascicularis is different from other Asian macaque groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02401811
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  • 6
    Digitale Medien
    Digitale Medien
    DNA polymorphisms in the ε- and γ-globin gene regions in asian macaques (1991)
    Springer
    Biochemical genetics 29 (1991), S. 189-202 
    Details
    ISSN: 1573-4927
    Schlagwort(e): DNA polymorphism ; ε-globin gene ; γ-globin gene ; macaques
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract DNA polymorphisms in the ε- and γ-globin gene regions in nine Asian macaques(Macaca fuscata, M. mulatta, M. nemestrina, M. cyclopis, M. fascicularis, M. arctoides, M. radiata, M. maura, andM. assamensis) were examined using several different restriction endonucleases and the human ε and γIVS2 probes.M. fuscata andM. mulatta had highly polymorphic sites(BglII andHincII, respectively) in the ε-globin gene region. TheBamHI site in the γ-globin gene region was highly polymorphic inM. mulatta, while theBglII andHindIII sites in the γ-globin gene region were highly polymorphic inM. fuscata andM. mulatta. The presence of the γ-globin gene triplication was frequently observed inM. fuscata. The gain or loss of an additionalBglII site between two γ-globin genes in Asian macaques seems to be very meaningful for discussing genetic relationships among them.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02401812
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  • 7
    Digitale Medien
    Digitale Medien
    Resist system based on the cationic photocrosslinking of poly(4-hydroxystyrene) and polyfunctional electrophiles (1993)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 31 (1993), S. 1-11 
    Details
    ISSN: 0887-624X
    Schlagwort(e): chemical amplification ; photoresist ; poly(p-hydroxystyrene) ; photocrosslinking ; carbocationic ; radiation-sensitive ; crosslinker ; triarylsulfonium salt ; thin-film chemistry ; UV ; E-beam ; x-ray ; Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: New resist systems based on acid-catalyzed, electrophilic aromatic substitution are described. These new resists show high sensitivity to deep UV and E-beam radiation with values approaching 2 mJ/cm2 and 2 μC/cm2, respectively. The resists are based on a three component system consisting of poly(4-hydroxystyrene), a polyfunctional, low molecular weight, latent electrophile, and a photoactive onium salt used as an acid generator. Irradiation of the resist film produces a latent image of acid dispersed in the matrix. During the postbaking step the photo-generated acid reacts with the latent polyfunctional electrophile and releases a reactive carbocationic intermediate with concomitant liberation of acetic acid. The carbocationic intermediate then reacts with neighboring phenolic moieties in a crosslinking reaction. The substitution reaction liberates a proton, making the process catalytic in nature, thus incorporating the concept of chemical amplification. These highly sensitive materials can be used as nonswelling negative multipurpose resists that function in deep-UV, x-ray or E-beam modes. © 1993 John Wiley & Sons, Inc.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pola.1993.080310101
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  • 8
    Digitale Medien
    Digitale Medien
    A new carbon fiber from lignin (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 44 (1992), S. 127-134 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: A new carbon fiber was prepared from the lignin (steam-exploded lignin), which was isolated from steam-exploded birch wood (Betula platyphylla). The lignin was modified to melt thermally on hydrogenolysis. The chloroform soluble and carbon disulfide insoluble fraction (HL) of the reaction products was heated at 300-350°C for 30 min, giving a molten viscous material (HHL). The HHL had a softening point of 110°C and melted at over 145°C to form viscous liquid. When HHL was subjected to a spinning test, according to a conventional fusion spinning method at a speed over 100 m/min, a fine filament could be continuously formed through a pinhole (diameter: 0.3 mm). After the filaments were heated in air at 1-2°C/min up to 210°C, by which time the filament was converted to have an infusible property, the filaments were carbonized by heating from a room temperature to 1000°C at a heating rate of 5°C/min in a stream of nitrogen. The typical properties of the lignin based carbon fiber were as follows: Fiber diameter = 7.6 ± 2.7μ Elongation = 1.63 ± 0.29% Tensile strength = 660 ± 230 MPa; Modulus of elasticity = 40.7 ± 6.3 GPa. The chemical structure of the precursor was remarkably changed from that of the original lignin, indicating the elimination of aliphatic functional groups implied originally in the starting material.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1992.070440113
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  • 9
    Digitale Medien
    Digitale Medien
    A new modification method of exploded lignin for the preparation of a carbon fiber precursor (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 48 (1993), S. 1485-1491 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: A lignin-pitch for carbon fiber was prepared in a high yield from exploded lignin on phenolysis followed by heat treatment under a vacuum. The lignin-pitch had an excellent spinnability in the melt state to form a fine filament. The green fibers were easily made infusible when heated in air at a relatively high heating rate (15-60°C/h). The lignin-based carbon fiber was produced in 43.7% of yield based on a starting material. The tensile strength was more than 400 MPa, indicating that the lignin-based carbon fiber is classified into a general purpose grade. © 1993 John Wiley & Sons, Inc.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1993.070480817
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  • 10
    Digitale Medien
    Digitale Medien
    Immobilization of cellulolytic and hemicellulolytic enzymes on inorganic supports (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 29 (1987), S. 236-241 
    Details
    ISSN: 0006-3592
    Schlagwort(e): Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Commercial cellulase preparations from Trichoderma viride and Aspergillus niger were immobilized on porous silica glass and ceramics such as alumina and titania with titanium tetrachloride (TiCl4) and on their silanized derivatives with glutaraldehyde (GLUT). The amounts of the immobilized enzymes were in the range 10-50 mg/g carrier (dry) depending on the kind of carrier and immobilization method. Their activities toward carboxymethyl cellulose (CMC), xylan, aryl-β-glucoside, and aryl-β-xyloside were 3-53% of those of the native enzymes. The optimum pH of the enzymes shifted to the acidic side in most cases, whereas the optimum temperatures were nearly the same as those of native ones. The activity of immobilized enzyme preparations towards CMC did not change significantly during continuous operation over a periods of 60 days. Finally, xylan was hydrolyzed with the immobilized enzymes, and the sugars formed were investigated.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bit.260290214
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