ISSN:
1432-0738
Keywords:
Key words Diethylstilbestrol
;
Structure
;
Carcinogenic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract An analysis of the structure of diethylstilbestrol (DES) indicates that neither DES nor any of its metabolites are potential mutagens. Moreover, the present analyses suggest (a) that the observed carcinogenic spectrum of DES reflects the activity of metabolic intermediates and (b) that the carcinogenicity of DES in mice is due to the presence of a 6 Å geometric descriptor that appears to be related to an estrogen receptor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002040050285
Permalink