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  • 1
    Electronic Resource
    Electronic Resource
    The effects of hyperthyroidism on the fine structure of the zona fasciculata of the rat adrenal cortexThis research supported by NIH grants DHEW 5T01 GM 00459 and 2R01 NS 00690. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 174 (1972), S. 451-467 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Chronic hyperthyroidism was induced in radiothyroidectomized and surgically thyroidectomized adult male rats by feeding a diet of 0.3-0.4% desiccated thyroid for four to ten week periods. Short term hyperthyroidism was induced in intact rats by the intraperitoneal injection of 250 μg/day of sodium levothyroxine for ten days. Adrenal glands were fixed by perfusion with 3% phosphate buffered glutaraldehyde and post-fixed in 1% osmium tetroxide. The zona fasciculata of the adrenal glands from experimental and control animals was examined in the electron microscope. Drastic mitochondrial alterations characterized the zona fasciculata of hyperthyroid rats. Initially, mitochondria became more nearly round and contained increased numbers of paracrystalline tubular inclusions of the type described by Kjaerheim ('67) and Wheatley ('68). In more altered states many mitochondria were filled with clusters of parallel tubular cristae of varying complexity which at times enveloped islands of mitochondrial matrix and fingers of cytoplasm which projected into the mitochondrion. Aggregations of numerous mitochondria occupied much of the cytoplasm of highly altered cells. Modifications of this nature have not been described following ACTH stimulation of the adrenal cortex. This raises the distinct possibility that thyroid effects on the adrenal cortex are not entirely ACTH mediated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091740405
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Observations on the fine structure of propylthiouracil-induced “brown degeneration” in the zona reticularis of mouse adrenal cortexThis research was supported by NIH grants GM 00459 and NS 00690, and the Veterans Administration Hospital, Tampa, Florida. (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 183 (1975), S. 293-302 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Propylthiouracil (6-propyl-2-thiouracil), an anti-thyroid agent, was fed to mice in a concentration equal to 0.1% of their diet for periods of 10 and 15 weeks. The cells of the inner zone of the adrenal cortex were examined with the electron microscope. In animals receiving propylthiouracil for ten weeks mitochondria were altered and the smooth endoplasmic reticulum (SER) showed a marked focal proliferation. In contrast to control animals rough endoplasmic reticulum was abundant and was frequently associated with the hyperplastic SER. After 15 weeks these alterations were no longer present but had been replaced by a spectrum of “brown degeneration.” The less affected cells were characterized by increased numbers of liposomes and lysosomes and the more affected cells by liposomal and mitochondrial degeneration. These observations emphasize that “brown degeneration” is a true degenerative process and not a spontaneous proliferation of ceroid pigment. It is suggested that the changes described may be directly related to an alteration in cholesterol metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091830206
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A comparative morphometric analysis of the effects of thyroxine and acth on the zona fasciculata of rat adrenal cortexAided by NIH Grant 5 S01 RR05749-02 (1976)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 145 (1976), S. 517-523 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The effects of thyroxine and ACTH on the ultrastructure of cells of the adrenal zona fasciculata were studied by morphometric analysis and compared by two-way analysis of variance. The results indicate that the effects of thyroxine and ACTH are different and independent. The statistically significant differences in effect of thyroxine and ACTH are: thyroxine causes an increase in the volume fraction of mitochondria and a decrease in the volume fraction of endoplasmic reticulum independent of ACTH; thyroxine causes a decrease in surface density of mitochondria and endoplasmic reticulum in the absence of ACTH, but in the presence of ACTH this effect is moderated by an interaction of thyroxine and ACTH. There were no statistically significant effects of either thyroxine or ACTH on volume fraction or surface density of liposomes.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001450409
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    Paper (German National Licenses)
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